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1. WO2020005964 - BONE TARGETED ANTIMICROBIAL OXAZOLIDINONE RELATED COMPOUNDS, FORMULATIONS THEREOF, AND USES THEREOF

Publication Number WO/2020/005964
Publication Date 02.01.2020
International Application No. PCT/US2019/039018
International Filing Date 25.06.2019
IPC
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
66
Phosphorus compounds
662
Phosphorus acids or esters thereof having P-C bonds, e.g. foscarnet, trichlorfon
663
Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19
Drugs for skeletal disorders
08
for bone diseases, e.g. rachitism, Paget's disease
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04
Antibacterial agents
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
F
ACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9
Compounds containing elements of the 5th Group of the Periodic System
02
Phosphorus compounds
28
with one or more P-C bonds
38
Phosphonic acids (R-P(:O)(OH)2); Thiophosphonic acids
A61K 31/663 (2006.01)
A61P 19/08 (2006.01)
A61P 31/04 (2006.01)
C07F 9/38 (2006.01)
CPC
A61K 31/663
A61P 19/08
A61P 31/04
C07F 9/386
C07F 9/3869
C07F 9/3873
Applicants
  • EBETINO, Frank Hallock [US/US]; US
  • SUN, Shuting [US/US]; US
  • MCKENNA, Charles E. [US/US]; US
  • SADRERAFI, Keivan [US/US]; US
  • CHERIAN, Philip [US/US]; US
Inventors
  • EBETINO, Frank Hallock; US
  • SUN, Shuting; US
  • MCKENNA, Charles E.; US
  • SADRERAFI, Keivan; US
  • CHERIAN, Philip; US
Agents
  • DEVEAU, Todd; US
Priority Data
62/690,05326.06.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) BONE TARGETED ANTIMICROBIAL OXAZOLIDINONE RELATED COMPOUNDS, FORMULATIONS THEREOF, AND USES THEREOF
(FR) COMPOSÉS ASSOCIÉS D'OXAZOLIDINONE ANTIMICROBIENS CIBLÉS SUR L'OS, LEURS FORMULATIONS, ET LEURS UTILISATIONS
Abstract
(EN)
Described herein are bisphosphonate oxazolidinone compounds, and conjugates and pharmaceutical formulations thereof, that can include a bisphosphonate and an oxazolidinone (or an oxazolidinone antimicrobial or antibiotic agent, substituent or derivative thereof), where the oxazolidinone can be releasably coupled to the bisphosphonate. Also provided herein are methods of making and methods of using the bisphosphonate oxazolidinone compounds, conjugates and pharmaceutical formulations thereof. Also provided herein are methods of use of the compounds, conjugates and formulations for treating a bone disease or for use in preparing a formulation for the treatment a bone disease.
(FR)
L'invention concerne des composés d'oxazolidinone bisphosphonate, et leurs conjugués et formulations pharmaceutiques, qui peuvent comprendre un bisphosphonate et une oxazolidinone (ou un agent antimicrobien ou antibiotique d'oxazolidinone, son substituant ou son dérivé), l'oxazolidinone pouvant être couplée de manière amovible au bisphosphonate. L'invention concerne également des procédés de fabrication et des procédés d'utilisation des composés de d'oxazolidinone bisphosphonate, de leurs conjugués et formulations pharmaceutiques. L'invention concerne également des procédés d'utilisation des composés, des conjugués et des formulations pour le traitement d'une maladie osseuse ou pour une utilisation dans la préparation d'une formulation pour le traitement d'une maladie osseuse.
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