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1. WO2020005945 - IMMUNOCONJUGATES TARGETING ADAM9 AND METHODS OF USE THEREOF

Publication Number WO/2020/005945
Publication Date 02.01.2020
International Application No. PCT/US2019/038992
International Filing Date 25.06.2019
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
40
against enzymes
[IPC code unknown for A61K 47/68]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
C07K 16/28 (2006.01)
A61P 35/00 (2006.01)
C07K 16/40 (2006.01)
A61K 47/68 (2017.01)
A61K 39/00 (2006.01)
CPC
A61K 2039/505
A61K 47/6803
A61K 47/6871
A61K 47/6889
A61P 35/00
C07K 16/2896
Applicants
  • IMMUNOGEN, INC. [US/US]; 830 Winter Street Waltham, MA 02451, US
  • MACROGENICS, INC. [US/US]; 9704 Medical Center Drive Rockville, MD 20850, US
Inventors
  • HICKS, Stuart, William; US
  • YODER, Nicholas, C.; US
  • BARAT, Bhaswati; US
  • BONVINI, Ezio; US
  • DIEDRICH, Gundo; US
  • JOHNSON, Leslie S.; null
  • LOO, Deryk; US
  • SCRIBNER, Juniper, A.; US
Agents
  • DAVIS, Steven G.; US
  • BAI, Mei; US
  • BROWN, Ronald, E.; US
  • DAVIS, Steven, G.; US
  • BOWLES, Anita, M.; US
Priority Data
62/690,05226.06.2018US
62/691,34228.06.2018US
62/810,70326.02.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) IMMUNOCONJUGATES TARGETING ADAM9 AND METHODS OF USE THEREOF
(FR) IMMUNOCONJUGUÉS CIBLANT L'ADAM9 ET MÉTHODES D'UTILISATION ASSOCIÉS
Abstract
(EN)
The present invention is directed to immunoconjugates comprising an antibody or fragment thereof capable of specifically binding to "Disintegrin and Metalloproteinase Domain- containing Protein 9" ("ADAM9") conjugated to at least one maytansinoid compound. The invention particularly concerns such immunoconjugates that are cross-reactive with human ADAM9 and the ADAM9 of a non-human primate (e.g., a cynomolgus monkey). The invention additionally pertains to all such immunoconjugates that comprise a Light Chain Variable (VL) Domain and/or a Heavy Chain Variable (VH) Domain that has been humanized and/or deimmunized so as to exhibit reduced immunogenicity upon administration of such immunoconjugate to a recipient subject. The invention is also directed to pharmaceutical compositions that contain any of such immunoconjugates, and to methods involving the use of any of such immunoconjugates in the treatment of cancer and other diseases and conditions.
(FR)
La présente invention concerne des immunoconjugués comprenant un anticorps ou un fragment de celui-ci capable se lier de manière spécifique à la « protéine 9 contenant un domaine de disintégrine et de métalloprotéinase » (« ADAM9 ») conjugué à au moins un composé maytansinoïde. En particulier, l'invention concerne de tels immunoconjugués qui peuvent réaliser une réaction croisée avec l'ADAM 9 humaine et l'ADAM 9 d'un primate non humaine (par exemple, un macaque crabier). L'invention concerne en outre l'ensemble de tels immunoconjugués qui comprennent un domaine variable à chaîne légère (VL) et/ou un domaine variable à chaîne lourde (VH) qui a été humanisé et/ou désimmunisé de sorte à présenter une immunogénicité réduite après administration d'un tel immunoconjugué à un sujet receveur. L'invention concerne également des compositions pharmaceutiques qui contiennent l'un quelconque de tels immunoconjugués, et des méthodes mettant en œuvre l'utilisation de l'un quelconque de tels immunoconjugués dans le traitement du cancer et d'autres maladies et affections.
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