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1. (WO2020005938) COMPOSITIONS AND METHODS FOR TREATING TISSUE INJURY
Latest bibliographic data on file with the International BureauSubmit observation

Pub. No.: WO/2020/005938 International Application No.: PCT/US2019/038982
Publication Date: 02.01.2020 International Filing Date: 25.06.2019
IPC:
A61K 31/4166 (2006.01) ,A61P 9/10 (2006.01) ,C07C 13/547 (2006.01) ,C07D 233/76 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4164
1,3-Diazoles
4166
having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
10
for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
13
Cyclic hydrocarbons containing rings other than, or in addition to, six-membered aromatic rings
28
Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof
32
with condensed rings
54
with three condensed rings
547
at least one ring not being six-membered, the other rings being at the most six-membered
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
233
Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
54
having two double bonds between ring members or between ring members and non-ring members
66
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
72
Two oxygen atoms, e.g. hydantoin
76
with substituted hydrocarbon radicals attached to the third ring carbon atom
Applicants:
CASE WESTERN RESERVE UNIVERSITY [US/US]; 10900 Euclid Avenue Cleveland, Ohio 44106, US
Inventors:
STAMLER, Jonathan S.; US
Agent:
SUTKUS, Richard A.; US
Priority Data:
62/689,41625.06.2018US
Title (EN) COMPOSITIONS AND METHODS FOR TREATING TISSUE INJURY
(FR) COMPOSITIONS ET MÉTHODES POUR TRAITER UNE LÉSION TISSULAIRE
Abstract:
(EN) A method for preventing or treating a tissue injury and/or promoting tissue repair in a subject in need thereof, includes administering to the subject a therapeutically effective amount of an ADH inhibitor, AKR inhibitor, SCoR inhibitor, and/or PKM2 inhibitor.
(FR) L'invention concerne une méthode permettant de prévenir ou de traiter une lésion tissulaire et/ou de favoriser la réparation tissulaire chez un sujet qui en a besoin, qui consiste à administrer au sujet une quantité thérapeutiquement efficace d'un inhibiteur d'ADH, d'un inhibiteur d'AKR, d'un inhibiteur de SCoR et/ou d'un inhibiteur de PKM2.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)