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1. WO2020005313 - SPHINGOSINE PATHWAY MODULATING COMPOUNDS FOR THE TREATMENT OF CANCERS

Publication Number WO/2020/005313
Publication Date 02.01.2020
International Application No. PCT/US2018/067131
International Filing Date 21.12.2018
IPC
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
02
specific for leukemia
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4245
Oxadiazoles
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
215
Compounds containing amino and hydroxy groups bound to the same carbon skeleton
02
having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
22
the carbon skeleton being unsaturated
28
and containing six-membered aromatic rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
271
Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
02
not condensed with other rings
06
1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
A61P 35/02 (2006.01)
A61K 31/4245 (2006.01)
C07C 215/28 (2006.01)
C07D 271/06 (2006.01)
CPC
A61K 31/4245
A61P 35/02
C07D 271/06
Applicants
  • ENZO BIOCHEM, INC. [US/US]; 527 Madison Avenue New York, NY 10022, US
  • RABBANI, Elazar [US/US]; US
  • DONEGAN, James J. [US/US]; US
  • DIAMOND, Paul [US/US]; US
Inventors
  • RABBANI, Elazar; US
  • DONEGAN, James J.; US
  • DIAMOND, Paul; US
Agents
  • DIAMOND, Paul; US
Priority Data
16/017,30325.06.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) SPHINGOSINE PATHWAY MODULATING COMPOUNDS FOR THE TREATMENT OF CANCERS
(FR) COMPOSÉS MODULANT LA VOIE DE LA SPHINGOSINE POUR LE TRAITEMENT DE CANCERS
Abstract
(EN)
The invention provides methods and compositions for treating cancers and myeloproliferative disorders using sphingosine kinase-1 inhibitors, such as SK1-I, and selective sphingosine-1-phosphate receptor agonists, such as ozanimod.
(FR)
L'invention concerne des méthodes et des compositions pour traiter des cancers et des troubles myéloprolifératifs à l'aide d'inhibiteurs de sphingosine kinase-1, tels que le SK1-I, et des agonistes sélectifs de récepteurs de la sphingosine-1-phosphate, tels que l'ozanimod.
Latest bibliographic data on file with the International Bureau