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1. WO2020005115 - 3,5-SUBSTITUTED DERIVATIVES OF THIAZOLIDINE-2,4-DIONE HAVING ANTIMICROBIAL ACTIVITY

Publication Number WO/2020/005115
Publication Date 02.01.2020
International Application No. PCT/RU2019/050076
International Filing Date 03.06.2019
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
277
Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
02
not condensed with other rings
20
having two or three double bonds between ring members or between ring members and non-ring members
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
277
Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
02
not condensed with other rings
20
having two or three double bonds between ring members or between ring members and non-ring members
22
with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
24
Radicals substituted by oxygen atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
277
Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
02
not condensed with other rings
20
having two or three double bonds between ring members or between ring members and non-ring members
32
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
34
Oxygen atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
417
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
425
Thiazoles
427
not condensed and containing further heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
10
Antimycotics
C07D 277/20 (2006.01)
C07D 277/24 (2006.01)
C07D 277/34 (2006.01)
C07D 417/12 (2006.01)
A61K 31/427 (2006.01)
A61P 31/10 (2006.01)
CPC
A61K 31/427
A61P 31/10
C07D 277/20
C07D 277/24
C07D 277/34
C07D 417/12
Applicants
  • ЛЕВШИН, Игорь Борисович LEVSHIN, Igor Borisovich [RU/RU]; RU
Inventors
  • ЛЕВШИН, Игорь Борисович LEVSHIN, Igor Borisovich; RU
  • ГРАММАТИКОВА, Наталия Эдуардовна GRAMMATIKOVA, Natalia Eduardovna; RU
  • ВАНЦКУЛ, Антон Сергеевич VANTSKUL, Anton Sergeevich; RU
  • ВАСИЛЬЕВА, Наталья Всеволодовна VASILIEVA, Natalia Vsevolodovna; RU
  • БОГОМОЛОВА, Татьяна Сергеевна BOGOMOLOVA, Tatiana Sergeevna; RU
Agents
  • КОТЛОВ, Дмитрий Владимирович KOTLOV, Dmitry Vladimirovich; RU
Priority Data
201812353528.06.2018RU
Publication Language Russian (RU)
Filing Language Russian (RU)
Designated States
Title
(EN) 3,5-SUBSTITUTED DERIVATIVES OF THIAZOLIDINE-2,4-DIONE HAVING ANTIMICROBIAL ACTIVITY
(FR) DÉRIVÉS 3,5-SUBSTITUÉS DE THIAZOLIDIN-2,4-DIONE POSSÉDANT UNE ACTIVITÉ ANTIMICROBIENNE
(RU) 3,5-ЗАМЕЩЕННЫЕ ПРОИЗВОДНЫЕ ТИАЗОЛИДИН-2,4-ДИОНА, ОБЛАДАЮЩИЕ ПРОТИВОМИКРОБНОЙ АКТИВНОСТЬЮ
Abstract
(EN)
The invention relates to a new class of compounds characterized, in particular, by high antifungal activity, of general formula (I): formula (I) where X and R1-R3 have the values indicated in the description. The invention also relates to pharmaceutical compositions containing said compounds and to the use of the aforesaid compounds for the treatment and/or prophylaxis of various infectious diseases in a subject, in particular diseases caused by fungal infections, such as diseases caused by candida and filamentous pathogens.
(FR)
L'invention concerne une nouvelle classe de composés caractérisés notamment par une activité antimycosique élevée ayant une formule générale (I): formule (I) dans laquelle X, R1-R3 ont des valeurs indiquées dans le descriptif. L'invention concerne les compositions pharmaceutiques contenant ces composés et l'utilisation de ces composés dans le traitement et/ou la prévention de différentes maladies infectieuses chez un sujet, provoqués notamment par des infections mycosiques, par exemple, de maladies provoquées par des pathogènes de candidose et filamenteuses.
(RU)
Изобретение относится к новому классу соединений, характеризующихся, в частности, высокой противогрибковой активностью, общей формулы (I): формула (I), где X, R1-R3 имеют значения, указанные в описании. Изобретение также относится к фармацевтическим композициям, содержащим указанные соединения и к применению вышеуказанных соединений для лечения и/или профилактики различных инфекционных заболеваний у субъекта, в частности вызванных грибковыми инфекциями, например, заболеваний, вызванных кандидозными и филаментозными патогенами.
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