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1. WO2020004938 - PYRIDOPYRIMIDINONE DERIVATIVES FOR USE AS AXL INHIBITORS

Publication Number WO/2020/004938
Publication Date 02.01.2020
International Application No. PCT/KR2019/007733
International Filing Date 26.06.2019
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
C07D 471/04 (2006.01)
CPC
A61K 31/519
C07D 471/04
Applicants
  • 주식회사 오스코텍 OSCOTEC INC. [KR/KR]; 경기도 성남시 분당구 대왕판교로 700, A동 901호 A-901, 700, Daewangpangyo-ro, Bundang-gu, Seongnam-si, Gyeonggi-do 13488, KR
Inventors
  • KIM, Jung-Ho; KR
  • 최장식 CHOI, Jang-Sik; KR
  • LEE, Hee Kyu; KR
  • 정동식 JUNG, Dong-Sik; KR
  • PARK, Sung-Ho; KR
  • CHOI, Yung-Geun; KR
Agents
  • 제일특허법인(유) FIRSTLAW P.C.; 서울시 서초구 마방로 60 60 Mabang-Ro, Seocho-Ku, Seoul 06775, KR
Priority Data
62/690,62027.06.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PYRIDOPYRIMIDINONE DERIVATIVES FOR USE AS AXL INHIBITORS
(FR) DÉRIVÉS DE PYRIDOPYRIMIDINONE DESTINÉS À ÊTRE UTILISÉS COMME INHIBITEURS D'AXL
Abstract
(EN)
Pyridopyrimidinone derivatives and pharmaceutical compositions comprising the same for use as an Axl inhibitor for the treatment of a disease or condition mediated by Axl such as multiple types of cancer and metastasis, are disclosed. Also disclosed are methods for treating a Axl-mediated disease or condition by administering to a subject a therapeutically effective amount of the pyridopyrimidinone derivatives.
(FR)
L'invention concerne des dérivés de pyridopyrimidinone et des compositions pharmaceutiques les comprenant pour une utilisation en tant qu'inhibiteur d'Axl pour le traitement d'une maladie ou d'une affection à médiation par Axl, tels que de multiples types de cancer et de métastases. L'invention concerne également des méthodes de traitement d'une maladie ou d'une affection à médiation par Axl, consistant à administrer à un sujet une quantité thérapeutiquement efficace des dérivés de pyridopyrimidinone.
Latest bibliographic data on file with the International Bureau