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1. WO2020004813 - TWO-COMPONENT HEMOSTATIC COMPOSITION AND METHOD OF MANUFACTURING SAME

Publication Number WO/2020/004813
Publication Date 02.01.2020
International Application No. PCT/KR2019/006003
International Filing Date 10.05.2019
IPC
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
715
Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
716
Glucans
722
Chitin; Chitosan
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
715
Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
716
Glucans
717
Celluloses
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
715
Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
716
Glucans
721
Dextrans
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
715
Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
726
Glycosaminoglycans, i.e. mucopolysaccharides
728
Hyaluronic acid
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
06
Ointments; Bases therefor
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
7
Drugs for disorders of the blood or the extracellular fluid
04
Antihaemorrhagics; Procoagulants; Haemostatatic agents; Antifibrinolytic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
26
Chemical aspects of, or use of materials for, liquid bandages
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
31
Materials for other surgical articles
14
Materials characterised by their function or physical properties
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
31
Materials for other surgical articles
14
Materials characterised by their function or physical properties
16
Biologically active materials, e.g. therapeutic substances
A61K 31/722 (2006.01)
A61K 31/717 (2006.01)
A61K 31/721 (2006.01)
A61K 31/728 (2006.01)
A61K 9/06 (2006.01)
A61P 7/04 (2006.01)
CPC
A61K 31/717
A61K 31/721
A61K 31/722
A61K 31/728
A61K 9/06
A61L 26/00
Applicants
  • 에스케이바이오랜드 주식회사 SK BIOLAND CO., LTD. [KR/KR]; 충청남도 천안시 동남구 병천면 송정리 2길 59 59, Songjeongni 2-gil Byeongcheon-myeon Dongnam-gu Chungcheongnam-do 31257, KR
Inventors
  • 김다연 KIM, Da Yeon; KR
  • 한민의 HAN, Min Eui; KR
  • 박기수 PARK, Ki Su; KR
  • 주지훈 JOO, Ji Hoon; KR
  • 양은경 YANG, Eun Kyung; KR
Agents
  • 이문섭 LEE, Moon-Sup; 서울시 관악구 남부순환로 1922, 청동빌딩 301호 Suite 301, Chungdong Building, 1922, Nambusunhwanro Gwanak-gu Seoul 08793, KR
Priority Data
10-2018-007456128.06.2018KR
Publication Language Korean (KO)
Filing Language Korean (KO)
Designated States
Title
(EN) TWO-COMPONENT HEMOSTATIC COMPOSITION AND METHOD OF MANUFACTURING SAME
(FR) COMPOSITION HÉMOSTATIQUE À DEUX CONSTITUANTS ET SON PROCÉDÉ DE PRÉPARATION
(KO) 2액형 지혈제 조성물 및 그 제조방법
Abstract
(EN)
The present invention relates to a two-component hemostatic composition which can be adjunctively used for a wide range of bleeding and surgeries, and a method for manufacturing same. The two-component hemostatic composition according to the present invention comprises, without comprising a blood preparation: a first solution containing chitosan; and a second solution containing a glucose- or cellulose-based compound, and can be easily applied in a liquid form to a wound or a surgical bleeding site of a human body and instantly form a hydrogel on the bleeding site to help hemostasis and recovery.
(FR)
La présente invention concerne une composition hémostatique à deux constituants qui peut être utilisée en complément pour une large gamme de saignements et de chirurgies, et son procédé de fabrication. Selon la présente invention, la composition hémostatique à deux constituants comprend, sans comprendre une préparation à base de sang : une première solution contenant du chitosane; et une seconde solution contenant un composé à base de glucose ou de cellulose, et peut être facilement appliquée sous forme liquide à une plaie ou à un site de saignement chirurgical d'un corps humain et former instantanément un hydrogel sur le site de saignement en vue d'aider à l'hémostase et à la cicatrisation.
(KO)
본 발명은 광범위한 출혈 및 수술 중 보조적으로 사용할 수 있는 2액형 지혈제 조성물 및 그 제조방법에 관한 것이다. 본 발명에 따른 2액형 지혈제 조성물은 혈액제제를 포함하지 않고,키토산(chitosan)을 함유하는 제 1용액 과 글루코오스(glucose) 혹은 셀루로오스계(cellulose) 화합물을 함유하는 제 2 용액을 포함하는 것을 특징으로 하며, 액상형으로 인체의 상처나 수술 출혈 부위에 쉽게 도포되고 출혈부위에서 즉석으로 하이드로젤을 형성하여 지혈 및 회복에 도움을 줄수 있다.
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