Processing

Please wait...

Settings

Settings

1. WO2020004709 - COMPOSITION COMPRISING ERIGERON ANNUUS FLOWER ESSENTIAL OIL FOR PREVENTION AND TREATMENT OF NEUROMUSCULAR DISEASE

Publication Number WO/2020/004709
Publication Date 02.01.2020
International Application No. PCT/KR2018/010592
International Filing Date 11.09.2018
IPC
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36
Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18
Magnoliophyta (angiosperms)
185
Magnoliopsida (dicotyledons)
28
Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43
Enzymes; Proenzymes; Derivatives thereof
46
Hydrolases (3)
48
acting on peptide bonds (3.4)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8
Cosmetics or similar toilet preparations
18
characterised by the composition
92
Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8
Cosmetics or similar toilet preparations
18
characterised by the composition
30
containing organic compounds
64
Proteins; Peptides; Derivatives or degradation products thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
21
Drugs for disorders of the muscular or neuromuscular system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
Q
SPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
19
Preparations for care of the skin
A61K 36/28 (2006.01)
A61K 38/48 (2006.01)
A61K 8/92 (2006.01)
A61K 8/64 (2006.01)
A61P 21/00 (2006.01)
A61Q 19/00 (2006.01)
CPC
A61K 36/28
A61K 38/48
A61K 8/64
A61K 8/92
A61P 21/00
A61Q 19/00
Applicants
  • 호서대학교 산학협력단 HOSEO UNIVERSITY ACADEMIC COOPERATION FOUNDATION [KR/KR]; 충청남도 아산시 배방읍 호서로79번길 20 20, Hoseo-ro 79beon-gil, Baebang-eup Asan-si Chungcheongnam-do 31499, KR
Inventors
  • 이환명 LEE, Hwan-Myung; KR
  • 황대일 HWANG, Dae-Il; KR
  • 김도윤 KIM, Do-Yoon; KR
  • 박수민 PARK, Soo-Min; KR
  • 김하빈 KIM, Ha-Bin; KR
Agents
  • 위병갑 WIE, Byoung-Gap; KR
Priority Data
10-2018-007515929.06.2018KR
Publication Language Korean (KO)
Filing Language Korean (KO)
Designated States
Title
(EN) COMPOSITION COMPRISING ERIGERON ANNUUS FLOWER ESSENTIAL OIL FOR PREVENTION AND TREATMENT OF NEUROMUSCULAR DISEASE
(FR) COMPOSITION COMPRENANT DE L'HUILE ESSENTIELLE DE FLEUR DE VERGERETTE ANNUELLE POUR LA PRÉVENTION ET LE TRAITEMENT D'UNE MALADIE NEUROMUSCULAIRE
(KO) 개망초 꽃 에센셜 오일을 포함하는 신경 근육 관련 질환 예방 및 치료용 조성물
Abstract
(EN)
The present invention relates to a pharmaceutical composition comprising a combination of Erigeron annuus flower essential oil and botulinum toxin (Botox) for prevention or treatment of neuromuscular disease and a pharma-beauty composition comprising the combination. The Erigeron annuus flower essential oil suppresses the expression of t-SNARE protein and v-SNARE protein in neurons to inhibit the formation of the SNARE protein complex and suppresses the regeneration of botulinum toxin-cleaved t-SNARE protein and v-SNARE protein to inhibit the release of neurotransmitters, thereby prolonging a retention period of the botulinum toxin effect. Accordingly, the Erigeron annuus flower essential oil can be used as an aid in combination with botulinum toxin, finding useful applications in the prevention or treatment of neuromuscular disease or in beauty purposes.
(FR)
La présente invention concerne une composition pharmaceutique comprenant une combinaison d'huile essentielle de fleur de vergerette annuelle (Erigeron annuus) et de toxine botulique (Botox) pour la prévention ou le traitement d'une maladie neuromusculaire et une composition pharmaceutique de beauté comprenant la combinaison. L'huile essentielle de fleur de vergerette annuelle inhibe l'expression de la protéine t-SNARE et de la protéine v-SNARE dans les neurones afin d'inhiber la formation du complexe protéique SNARE et inhibe la régénération des protéines t-SNARE et v-SNARE clivées par la toxine botulique afin d'inhiber la libération de neurotransmetteurs, prolongeant ainsi la durée de persistance de l'effet de la toxine botulique. Par conséquent, l'huile essentielle de fleur de vergerette annuelle peut être utilisée en tant qu'adjuvant en combinaison avec la toxine botulique, trouver des applications utiles dans la prévention ou le traitement d'une maladie neuromusculaire ou à des fins esthétiques.
(KO)
본 발명은 개망초 꽃 에센셜 오일(essential oil) 및 보톡스(Botox)를 병용하여 포함하는 신경 근육 관련 질환의 예방 또는 치료용 약학적 조성물 및 미용약학적 조성물에 관한 것으로, 상기 개망초 꽃 에센셜 오일은 신경세포에서 t-SNARE 단백질 및 v-SNARE 단백질 발현을 억제하여 SNARE 단백질 복합체 형성을 억제하고, 보톡스에 의해 분해된 t-SNARE 단백질 및 v-SNARE 단백질의 재생을 억제함으로써 신경전달물질 분비를 억제하는 효과를 가지며, 이에 따라 보톡스의 효과 유지 기간을 연장시킬 수 있으므로, 개망초 꽃 에센셜 오일을 보톡스 보조제로서 보톡스와 병용하여 신경 근육 관련 질환의 예방, 치료 또는 미용을 위한 용도로 유용하게 사용할 수 있다.
Latest bibliographic data on file with the International Bureau