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1. WO2020004490 - ANTIBODY BINDING TO CHONDROITIN SULFATE PROTEOGLYCAN-5

Publication Number WO/2020/004490
Publication Date 02.01.2020
International Application No. PCT/JP2019/025450
International Filing Date 26.06.2019
IPC
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
12
Genes encoding animal proteins
13
Immunoglobulins
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
[IPC code unknown for A61K 47/56]
[IPC code unknown for A61K 47/60]
[IPC code unknown for A61K 47/68]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
50
Electrically conductive preparations for use in therapy or testing in vivo, e.g. conductive adhesives or gels to be used with electrodes for electrocardiography (ECG) or for transcutaneous drug administration
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
51
Preparations containing radioactive substances for use in therapy or testing in vivo
02
characterised by the carrier
04
Organic compounds
08
Peptides, e.g. proteins
10
Antibodies or immunoglobulins; Fragments thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29
Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1
Micro-organisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving micro-organisms or compositions thereof; Processes of preparing or isolating a composition containing a micro-organism; Culture media therefor
14
Fungi; Culture media therefor
15
modified by introduction of foreign genetic material
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1
Micro-organisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving micro-organisms or compositions thereof; Processes of preparing or isolating a composition containing a micro-organism; Culture media therefor
14
Fungi; Culture media therefor
16
Yeasts; Culture media therefor
19
modified by introduction of foreign genetic material
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1
Micro-organisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving micro-organisms or compositions thereof; Processes of preparing or isolating a composition containing a micro-organism; Culture media therefor
20
Bacteria; Culture media therefor
21
modified by introduction of foreign genetic material
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
10
Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
21
Preparation of peptides or proteins
08
Monoclonal antibodies
C12N 15/13 (2006.01)
A61K 39/395 (2006.01)
A61K 47/56 (2017.01)
A61K 47/60 (2017.01)
A61K 47/68 (2017.01)
A61K 50/00 (2006.01)
CPC
A61K 39/395
A61K 47/56
A61K 47/60
A61K 47/68
A61K 51/10
A61P 25/00
Applicants
  • 協和キリン株式会社 KYOWA KIRIN CO., LTD. [JP/JP]; 東京都千代田区大手町一丁目9番2号 1-9-2, Otemachi, Chiyoda-ku, Tokyo 1000004, JP
  • 国立大学法人 鹿児島大学 KAGOSHIMA UNIVERSITY [JP/JP]; 鹿児島県鹿児島市郡元一丁目21番24号 21-24, Korimoto 1-chome, Kagoshima-shi, Kagoshima 8908580, JP
Inventors
  • 高橋 信明 TAKAHASHI Nobuaki; JP
  • 中野 了輔 NAKANO Ryosuke; JP
  • 前田 さやか MAEDA Sayaka; JP
  • 伊東 祐二 ITO Yuji; JP
Agents
  • 特許業務法人栄光特許事務所 Eikoh Patent Firm, P.C.; JP
Priority Data
2018-12047626.06.2018JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) ANTIBODY BINDING TO CHONDROITIN SULFATE PROTEOGLYCAN-5
(FR) ANTICORPS SE LIANT AU PROTÉOGLYCANE-5 À CHONDROÏTINE SULFATE
(JA) コンドロイチン硫酸プロテオグリカン-5に結合する抗体
Abstract
(EN)
The present invention relates to: an antibody or a fragment of said antibody that binds to chondroitin sulfate proteoglycan-5 (CSPG5); a hybridoma that produces the antibody or the antibody fragment; a nucleic acid that contains a base sequence coding for the antibody or the antibody fragment; a transformed cell that contains a vector containing said nucleic acid; a method for manufacturing the antibody or the antibody fragment; a composition containing the antibody or the antibody fragment; a method for detecting or measuring an antigen present in the brain by employing the antibody or the antibody fragment; a method for diagnosing or treating a brain disease; a method for enhancing the retention of the antibody in the brain; a method for increasing the antibody quantity in the brain; and so forth.
(FR)
La présente invention concerne : un anticorps ou un fragment dudit anticorps qui se lie au protéoglycane-5 à chondroïtine sulfate (CSPG5) ; un hybridome qui produit l'anticorps ou le fragment d'anticorps ; un acide nucléique qui contient une séquence de base codant pour l'anticorps ou le fragment d'anticorps ; une cellule transformée qui contient un vecteur contenant ledit acide nucléique ; une méthode de fabrication de l'anticorps ou du fragment d'anticorps ; une composition contenant l'anticorps ou le fragment d'anticorps ; une méthode de détection ou de mesure d'un antigène présent dans le cerveau en utilisant l'anticorps ou le fragment d'anticorps ; une méthode pour diagnostiquer ou traiter une maladie du cerveau ; une méthode pour améliorer la rétention de l'anticorps dans le cerveau ; une méthode pour augmenter la quantité d'anticorps dans le cerveau ; etc.
(JA)
本発明は、コンドロイチン硫酸プロテオグリカン-5(Chondroitin sulfate proteoglycan 5;CSPG5)に結合する抗体または該抗体断片、該抗体または該抗体断片を産生するハイブリドーマ、該抗体または該抗体断片をコードする塩基配列を含む核酸、該核酸を含むベクターを含む形質転換細胞、該抗体または該抗体断片の製造方法、該抗体または該抗体断片を含む組成物、該抗体または該抗体断片を用いた脳に存在する抗原を検出または測定する方法、脳疾患を診断または治療する方法、抗体の脳滞留性を向上させる方法、脳内の抗体量を増加させる方法などに関する。
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