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1. WO2020004443 - ARENAVIRUS GROWTH INHIBITOR COMPRISING POLYCYCLIC CARBAMOYL PYRIDONE DERIVATIVE

Publication Number WO/2020/004443
Publication Date 02.01.2020
International Application No. PCT/JP2019/025312
International Filing Date 26.06.2019
IPC
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
535
having six-membered rings with at least one nitrogen and at least one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
5375
1,4-Oxazines, e.g. morpholine
5383
ortho- or peri-condensed with heterocyclic ring systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
4985
Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
53
having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
535
having six-membered rings with at least one nitrogen and at least one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
5365
ortho- or peri-condensed with heterocyclic ring systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
55
having seven-membered rings, e.g. azelastine, pentylenetetrazole
551
having two nitrogens as ring hetero atoms, e.g. clozapine, dilazep
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12
Antivirals
14
for RNA viruses
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A61K 31/5383 (2006.01)
A61K 31/4985 (2006.01)
A61K 31/53 (2006.01)
A61K 31/5365 (2006.01)
A61K 31/551 (2006.01)
A61P 31/14 (2006.01)
CPC
A61K 31/4985
A61K 31/53
A61K 31/5365
A61K 31/5383
A61K 31/551
A61P 31/14
Applicants
  • 国立大学法人北海道大学 NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY [JP/JP]; 北海道札幌市北区北8条西5丁目 Kita 8-jyo Nishi 5-chome, Kita-ku, Sapporo-shi, Hokkaido 0600808, JP
  • 塩野義製薬株式会社 SHIONOGI & CO., LTD. [JP/JP]; 大阪府大阪市中央区道修町3丁目1番8号 1-8, Doshomachi 3-chome, Chuo-ku, Osaka-shi, Osaka 5410045, JP
Inventors
  • 石井 秋宏 ISHII Akihiro; JP
  • 佐藤 彰彦 SATO Akihiko; JP
  • 河井 真 KAWAI Makoto; JP
  • 垰田 善之 TAODA Yoshiyuki; JP
Agents
  • 杉田 健一 SUGITA Ken-ichi; JP
  • 渡部 秀昭 WATANABE Hideaki; JP
Priority Data
2018-12246727.06.2018JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) ARENAVIRUS GROWTH INHIBITOR COMPRISING POLYCYCLIC CARBAMOYL PYRIDONE DERIVATIVE
(FR) INHIBITEUR DE LA CROISSANCE D'ARÉNAVIRUS COMPRENANT UN DÉRIVÉ DE CARBAMOYLPYRIDONE POLYCYCLIQUE
(JA) 多環性カルバモイルピリドン誘導体を含有するアレナウイルス増殖阻害剤
Abstract
(EN)
The purpose of the present invention is to provide a compound having an antiviral effect, in particular, an activity of inhibiting the growth of an arenavirus, and/or a medicine comprising the compound. An arenavirus growth inhibitor that comprises a compound represented by formula (I) [wherein: R1 represents carboxy, etc.; A3 represents CR2 or N; R2 represents a hydrogen atom, halogen, hydroxy, etc.; R3 represents a hydrogen atom, hydroxy, carboxy, cyano, formyl, an alkyl optionally substituted by substituents F, etc.; one of A1 and A2 represents CR5R6 while the other represents NR7, or A1 represents CR8R9 and A2 represents CR10R11; and R5, R6, R7, R8, R9, R10 and R11 independently represent a a hydrogen atom, carboxy, cyano, an alkyl optionally substituted by substituents F, etc.], a prodrug thereof or a pharmaceutically acceptable salt of the same.
(FR)
L'objectif de la présente invention est de fournir un composé possédant un effet antiviral, en particulier une activité d'inhibition de la croissance d'un arénavirus, et/ou un médicament comprenant le composé. L'invention concerne un inhibiteur de la croissance d'arénavirus qui comprend un composé représenté par la formule (I) [dans laquelle : R1 représente carboxy, etc. ; A3 représente CR2 ou N ; R2 représente un atome d'hydrogène, un halogène, un hydroxy, etc. ; R3 représente un atome d'hydrogène, un hydroxy, un carboxy, un cyano, un formyle, un alkyle éventuellement substitué par des substituants F, etc. ; A1 ou A2 représente CR5R6 tandis que l'autre représente NR7, ou A1 représente CR8R9 et A2 représente CR10R11 ; et R5, R6, R7, R8, R9, R10 et R11 représentent indépendamment un atome d'hydrogène, un carboxy, un cyano, un alkyle éventuellement substitué par des substituants F, etc.], son promédicament ou son sel pharmaceutiquement acceptable.
(JA)
本発明は、抗ウイルス作用、特にアレナウイルスの増殖抑制活性を有する化合物、および/または該化合物を含有する医薬を提供することである。式(I):(式中、R1は、カルボキシ等であり;A3は、CR2またはNであり;R2は、水素原子、ハロゲン、ヒドロキシ等であり;R3は、水素原子、ヒドロキシ、カルボキシ、シアノ、ホルミル、置換基群Fで置換されていてもよいアルキル等であり;A1およびA2は、いずれか一方がCR5R6、ならびに他方がNR7であるか、またはA1がCR8R9、およびA2がCR10R11であり;R5、R6、R7、R8、R9、R10、およびR11は、それぞれ独立して、水素原子、カルボキシ、シアノ、置換基群Fで置換されていてもよいアルキル等である)で示される化合物もしくはそのプロドラッグまたはその製薬上許容される塩、を含有するアレナウイルス増殖阻害剤。
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