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1. WO2020003204 - INHIBITION OF A TRIPARTITE VOR PROTEIN COMPLEX IN MULTICELLULAR ORGANISMS

Publication Number WO/2020/003204
Publication Date 02.01.2020
International Application No. PCT/IB2019/055462
International Filing Date 27.06.2019
IPC
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4196
1,2,4-Triazoles
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68
involving proteins, peptides or amino acids
G01N 33/50 (2006.01)
A61K 31/4196 (2006.01)
G01N 33/68 (2006.01)
CPC
A61K 31/4196
A61K 31/496
A61K 45/06
A61P 11/00
A61P 25/28
A61P 27/02
Applicants
  • LORICO, Aurelio [US/US]; US
  • CORBEIL, Denis [CA/DE]; DE
  • SANTOS, Mark F. [US/US]; US
  • RAPPA, Germana [IT/US]; US
Inventors
  • LORICO, Aurelio; US
  • CORBEIL, Denis; DE
  • SANTOS, Mark F.; US
  • RAPPA, Germana; US
Agents
  • MOTTA, Marcelo; GB
Priority Data
1810556.927.06.2018GB
62/690,61627.06.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) INHIBITION OF A TRIPARTITE VOR PROTEIN COMPLEX IN MULTICELLULAR ORGANISMS
(FR) INHIBITION D'UN COMPLEXE TRIPARTITE DE PROTÉINES VOR DANS DES ORGANISMES MULTICELLULAIRES
Abstract
(EN)
The present disclosure relates generally to methods of inhibiting a tripartite VAP-A, ORP3 and Rab7 (VOR) protein complex in multicellular organisms, to methods of identifying agents which inhibit such complex and to the medical use of those agents. Inhibition of the VOR complex causes interference with at least one mechanism of intercellular communication, wherein the intercellular communication is mediated by receptor-ligand interaction and/or EVs, and viral infection involving the transport of endocytosed biomaterials to the nucleus of recipient cells.
(FR)
La présente invention concerne d'une manière générale des procédés d'inhibition d'un complexe tripartite de protéines VAP-A, ORP3 et Rab7 (VOR) dans des organismes multicellulaires, des procédés d'identification d'agents qui inhibent un tel complexe et l'utilisation médicale de ces agents. L'inhibition du complexe VOR provoque une interférence avec au moins un mécanisme de communication intercellulaire, la communication intercellulaire étant médiée par une interaction récepteur-ligand et/ou des VE, et une infection virale impliquant le transport de biomatériaux endocytosés vers le noyau de cellules receveuses.
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