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1. WO2020002911 - NATURAL KILLER CELLS


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INTERNATIONAL SEARCH REPORT (ISR)
Part 1:  1  2  3  4  5  6          Part 2:  A  B  C  D  E 
International application No. Applicant's or agent's file reference
PCT/GB2019/051803 P51465WO
International filing date (day/month/year) (Earliest) Priority Date (day/month/year)
26 June 2019 26 June 2018
Applicant
IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND...
FOR FURTHER ACTION: See Form PCT/ISA/220 as well as, where applicable, item 5 below.
This international search report has been prepared by this International Searching Authority and is transmitted to the applicant according to Article 18. A copy is being transmitted to the International Bureau.
It is also accompanied by a copy of each prior art document cited in this report.
1. Basis of the report
a. With regard to the language, the international search was carried out on the basis of:
the international application in the language in which it was filed.
a translation of the international application into                                          which is the language of a translation furnished for the purposes of international search (Rules 12.3(a) and 23.1(b)).
b.
This international search report has been established taking into account the rectification of an obvious mistake authorized by or notified to this Authority under Rule 91 (Rule 43.6bis(a)).
c.
1. With regard to any nucleotide and/or amino acid sequence disclosed in the international application, the international search was carried out on the basis of a sequence listing:
a. forming part of the international application as filed:
in the form of an Annex C/ST.25 text file.
on paper or in the form of an image file.
b. furnished together with the international application under PCT Rule 13ter.1(a) for the purposes of international search only in the form of an Annex C/ST.25 text file.
c. furnished subsequent to the international filing date for the purposes of international search only:
in the form of an Annex C/ST.25 text file (Rule 13ter.1(a)).
on paper or in the form of an image file (Rule 13ter.1(b) and Administrative Instructions, Section 713).
2.
In addition, in the case that more than one version or copy of a sequence listing has been filed or furnished, the required statements that the information in the subsequent or additional copies is identical to that forming part of the application as filed or does not go beyond the application as filed, as appropriate, were furnished.
3.
Additional comments:
2. Certain claims were found unsearchable
3. Unity of invention is lacking
4. Title of the invention
The text is approved as submitted by the applicant.
The text has been established by this Authority to read as follows:
5. Abstract
The text is approved as submitted by the applicant.
The text has been established, according to Rule 38.2, by this Authority as it appears in Box No. IV. The applicant may, within one month from the date of mailing of this international search report, submit comments to this Authority.
6. Drawings
a.
The figure of the drawings to be published with the abstract is Figure No.     1    
as suggested by the applicant.
as selected by this Authority, because the applicant failed to suggest a figure.
as selected by this Authority, because this figure better characterizes the invention.
b.
none of the figures is to be published with the abstract.

A. CLASSIFICATION OF SUBJECT MATTER

     C12N 5/0783 (2010.01)i; C12N 5/0789 (2010.01)i; A61K 31/33 (2006.01)i
According to International Patent Classification (IPC) or to both national classification and IPC

B. FIELDS SEARCHED

Minimum documentation searched (classification system followed by classification symbols):
     A61K; C12N
Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched:
Electronic data base consulted during the international search (name of data base and, where practicable, search terms used):
EPO-Internal, BIOSIS, CHEM ABS Data, Sequence Search, EMBASE, WPI Data

C. DOCUMENTS CONSIDERED TO BE RELEVANT

Category* Citation of document, with indication, where appropriate, of the relevant passages Relevant to claim No.
(1)
X
KATO, HIDEO ET AL, "1-azabicyclo compounds. 20. Synthesis of hexahydroisoquino[3,2-c][1,4]benzodiazepine and related compounds and formation of 6-methyl-hexahydro-5H-dibenzo[b,g][1,5]diazacycloundecine from hexahydroisoquino[3,2-c][1,4]benzodiazepin-13-one", CA1975, retrieved from STNDatabase accession no. 1975:57654
Retrieved from the Internet:
URL:CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US
XP002794692
24
abstract; compounds 54625-61-5, 54625-62-6
& KATO, HIDEO ET AL, "1-azabicyclo compounds. 20. Synthesis of hexahydroisoquino[3,2-c][1,4]benzodiazepine and related compounds and formation of 6-methyl-hexahydro-5H-dibenzo[b,g][1,5]diazacycloundecine from hexahydroisoquino[3,2-c][1,4]benzodiazepin-13-one",  YAKUGAKU ZASSHI , 94(8), 934-44 CODEN: YKKZAJ; ISSN: 0031-6903,1974,
XP003002219
(2)
X
AKIYAMA, SHIGEAKI ET AL, "Preparation of pyrazolecarboxamide derivatives as plant disease control agents", CA1997, retrieved from STNDatabase accession no. 1997:77166
Retrieved from the Internet:
URL:CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US
XP002794693
24
abstract
& WO 9638419  A1  (NISSAN CHEMICAL IND LTD [JP]; AKIYAMA SHIGEAKI [JP] ET AL.) 05 December 1996 (1996-12-05)
(3)
X
RYDER, HAMISH ET AL, "CCK and/or gastrin receptor ligands", CA1994, retrieved from STNDatabase accession no. 1994:656334
Retrieved from the Internet:
URL:CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US
XP002794694
24
abstract
& WO 9320099  A2  (FERRING BV [NL]; YAMANOUCHI PHARMA CO LTD [JP] ET AL.) 14 October 1993 (1993-10-14)
(4)
X
Zheng, Meiqing ET AL, "(3S)-N-(-Aminoacyl)-1,2,3,4-tetrahydroisoquinolines, a class of novel antithrombotic agents: Synthesis, bioassay, 3D QSAR, and ADME analysis", CA2008, retrieved from STNDatabase accession no. 2008:1266488
Retrieved from the Internet:
URL:CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US
XP002794695
24
abstract
& ZHENG M ET AL, "(3S)-N-(l-Aminoacyl)-1,2,3,4-tetrahydroisoquinolines, a class of novel antithrombotic agents: Synthesis, bioassay, 3D QSAR, and ADME analysis", 01 November 2008 (2008-11-01), Vol. 16, No. 21, page 9574-9587,
XP025545782
[retrieved on  2008-09-12]
(5)
Y
WO 2013033310 A1 (KAMENECKA THEODORE MARK [US]; BURRIS THOMAS [US]) 07 March 2013 (2013-03-07)
1-24
cited in the application
pages 108, 109, 111, 112, 151, 152, 198, 199, 200;compounds 8, 12, 13, 17-19, 22, 122, 123, 125
(6)
Y
ROMAIN NOEL ET AL, "Synthesis and SAR of tetrahydroisoquinolines as Rev-erb agonists", 03 April 2012 (2012-04-03), Vol. 22, No. 11, page 3739-3742,
XP028423354
[retrieved on  2012-04-13]
1-24
table 1; compounds 1380547-63-6
(7)
Y
WO 2015103527 A1 (SCRIPPS RESEARCH INST [US]; KAMENECKA THEODORE MARK [US]) 09 July 2015 (2015-07-09)
1-23
cited in the application
claim 16
(8)
Y
DOUGLAS KOJETIN ET AL, "Identification of SR8278, a Synthetic Antagonist of the Nuclear Heme Receptor REV-ERB", ACS CHEMICAL BIOLOGY,Vol. 6, No. 2, 18 February 2011 (2011-02-18), page 131-134,
XP055100259
1-23
the whole document
(9)
X
Anonymous, "Glycine, N-(2-furanylmethyl)-N-(phenylmethyl)-, ethyl ester (CA INDEX NAME)", REGISTRY30 April 2012 (2012-04-30), Database accession no. 1371553-17-1
Retrieved from the Internet:
URL:CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US
XP002794696
24
compound
(10)
X
Anonymous, "Glycine, N-(2-furanylcarbonyl)-N-(phenylmethyl)-, ethyl ester (CA INDEX NAME)", REGISTRY10 November 2010 (2010-11-10), Database accession no. 1252548-43-8
Retrieved from the Internet:
URL:CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US
XP002794697
24
compound
(11)
Y
XIAOFEI YU ET AL, "T H 17 Cell Differentiation Is Regulated by the Circadian Clock", SCIENCE,Vol. 342, 08 November 2013 (2013-11-08), page 727-730,
XP055627555
1-23
page 728, middle column, last paragraph - right-hand column, paragraph 1; figure 3A
(12)
Y
US 2012282693 A1 (KIMBREL ERIN [US] ET AL) 08 November 2012 (2012-11-08)
1-23
paragraphs [0097] - [0098]
(13)
Y
CN 103710304 A (BEIJING DONGFANG BAIAO MEDICAL DEV CO LTD) 09 April 2014 (2014-04-09)
1-23
the whole document
(14)
X,P
WO 2018178666 A1 (IMPERIAL INNOVATIONS LTD [GB]) 04 October 2018 (2018-10-04)
1-24
claim 10
(15)
X,P
WO 2018158587 A1 (IMPERIAL INNOVATIONS LTD [GB]) 07 September 2018 (2018-09-07)
1-24
claim 8
*
Special categories of cited documents:
"A"
document defining the general state of the art which is not considered to be of particular relevance
"D"
document cited by the applicant in the international application
"E"
earlier application or patent but published on or after the international filing date
"L"
document which may throw doubts on priority claim(s) or which is cited to establish the publication date of another citation or other special reason (as specified)
"O"
document referring to an oral disclosure, use, exhibition or other means
"P"
document published prior to the international filing date but later than the priority date claimed
"T"
later document published after the international filing date or priority date and not in conflict with the application but cited to understand the principle or theory underlying the invention
"X"
document of particular relevance; the claimed invention cannot be considered novel or cannot be considered to involve an inventive step when the document is taken alone
"Y"
document of particular relevance; the claimed invention cannot be considered to involve an inventive step when the document is combined with one or more other such documents, such combination being obvious to a person skilled in the art
"&"
document member of the same patent family

D. INFORMATION ON PATENT FAMILY MEMBERS

Patent document cited in search report Publication date
(day/month/year)
Patent family member(s) Publication date
(day/month/year)
WO 2013033310 A1
07 March 2013
NONE
WO 2015103527 A1
09 July 2015
NONE
US 2012282693 A1
08 November 2012
AU 2010326027 A1
BR 112012014104 A2
CA 2781969 A1
CN 102822332 A
EP 2507365 A1
JP 6013187 B2
JP 2013512673 A
JP 2016119910 A
JP 2019083819 A
KR 20120112511 A
KR 20190016602 A
RU 2012127811 A
US 2012282693 A1
US 2015140657 A1
WO 2011068896 A1
21 June 2012
05 July 2016
09 June 2011
12 December 2012
10 October 2012
25 October 2016
18 April 2013
07 July 2016
06 June 2019
11 October 2012
18 February 2019
10 January 2014
08 November 2012
21 May 2015
09 June 2011
CN 103710304 A
09 April 2014
NONE
WO 2018178666 A1
04 October 2018
NONE
WO 2018158587 A1
07 September 2018
NONE
Name and mailing address of the ISA/:
European Patent Office
P.B. 5818, Patentlaan 2, 2280 HV Rijswijk,
Netherlands
Telephone No. (+31-70)340-2040
Facsimile No. (+31-70)340-3016
Date of the actual completion of the international search:
01 October 2019
Date of mailing of the international search report:
04 November 2019
Authorized officer:
Petri, Bernhard
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