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1. WO2020002905 - CANCER THERAPY

Publication Number WO/2020/002905
Publication Date 02.01.2020
International Application No. PCT/GB2019/051794
International Filing Date 25.06.2019
IPC
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
66
Materials from micro-organisms
74
Bacteria
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
04
specific for metastasis
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45
Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
06
Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61K 39/395 (2006.01)
A61K 35/74 (2015.01)
C07K 16/28 (2006.01)
A61P 35/04 (2006.01)
A61P 35/00 (2006.01)
A61K 45/06 (2006.01)
CPC
A61K 35/74
A61K 39/39558
A61K 45/06
A61P 35/00
A61P 35/04
C07K 16/28
Applicants
  • IMMODULON THERAPEUTICS LIMITED [GB/GB]; 475 Salisbury House London Wall London Greater London EC2M 5QQ, GB
Inventors
  • MARTYN, Glen; GB
  • KAMPINGA, Jakob; GB
  • BURTON, Graham; GB
  • DALGLEISH, Angus; GB
Agents
  • GILL JENNINGS & EVERY LLP; The Broadgate Tower 20 Primrose Street London EC2A 2ES, GB
  • JAPPY, John; GB
Priority Data
18179675.625.06.2018EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) CANCER THERAPY
(FR) THÉRAPIE ANTI-CANCÉREUSE
Abstract
(EN)
A non-viable, whole-cell Mycobacterium for use in the treatment, reduction, inhibition or control of one or more tumours in a checkpoint inhibitor refractory patient, wherein said checkpoint inhibitor refractory patient is intended to undergo checkpoint inhibition therapy simultaneously, separately or sequentially with administration of the Mycobacterium, and/or co-stimulatory checkpoint therapy, and optionally further comprising administering one or more additional anticancer treatments or agents.
(FR)
L'invention concerne une mycobactérie non viable, à cellules entières, destinée à être utilisée dans le traitement, la réduction, l'inhibition ou la régulation d'une ou plusieurs tumeurs chez un patient réfractaire à un inhibiteur de points de contrôle, ledit patient réfractaire à un inhibiteur de points de contrôle étant destiné à subir une thérapie d'inhibition de points de contrôle simultanément, séparément ou successivement avec l'administration de la mycobactérie, et/ou une thérapie de points de contrôle co-stimulatrice, et consistant éventuellement en outre à administrer un ou plusieurs traitements ou agents anti-cancéreux supplémentaires.
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