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1. (WO2020002862) METHODS FOR THE ANALYSIS OF CIRCULATING MICROPARTICLES
Latest bibliographic data on file with the International BureauSubmit observation

Pub. No.: WO/2020/002862 International Application No.: PCT/GB2018/053753
Publication Date: 02.01.2020 International Filing Date: 21.12.2018
IPC:
C12Q 1/6806 (2018.01) ,C12Q 1/6832 (2018.01) ,C12Q 1/6834 (2018.01) ,G01N 33/50 (2006.01) ,C12Q 1/68 (2018.01)
[IPC code unknown for C12Q 1/6806][IPC code unknown for C12Q 1/6832][IPC code unknown for C12Q 1/6834]
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
Applicants:
CS GENETICS LIMITED [GB/GB]; Botanic House 100 Hills Road Cambridge Cambridgeshire CB2 1PH, GB
Inventors:
EDELMAN, Lucas Brandon; GB
Agent:
BOULT WADE TENNANT LLP; Salisbury Square House 8 Salisbury Square London EC4Y 8AP, GB
Priority Data:
1810571.827.06.2018GB
18180259.628.06.2018EP
Title (EN) METHODS FOR THE ANALYSIS OF CIRCULATING MICROPARTICLES
(FR) PROCÉDÉS D'ANALYSE DE MICROPARTICULES CIRCULANTES
Abstract:
(EN) Reagents and methods for the analysis of cell free biomolecules (e.g. cell free nucleic acid molecules and cell free polypeptides) of circulating microparticles (i.e. microparticles originating from blood) are provided. The methods comprise analysing a sample that comprises a circulating microparticle or a sample derived from a circulating microparticle. The methods include methods of measuring at least two linked signals, each signal corresponding to the presence, absence and/or level of a biomolecule of a circulating microparticle. The methods also include methods of determining the presence, absence and/or level of a biomolecule of a ciruclatling microparticle using a barcoded affinity probe. In certain methods both nucleic acid biomolecules and non- nucleic acid biomolecules of a circulatling microparticle are analysed together. Reagents for use in the methods are also provided.
(FR) La présente invention concerne des réactifs et des procédés destinés à l'analyse de biomolécules sans cellule (par exemple, de molécules d'acide nucléique sans cellule et de polypeptides sans cellule) de microparticules circulantes (c'est-à-dire de microparticules provenant du sang). Les procédés comprennent l'analyse d'un échantillon qui comprend une microparticule circulante ou un échantillon dérivé d'une microparticule circulante. Les procédés comportent des procédés de mesure d'au moins deux signaux liés, chaque signal correspondant à la présence, à l'absence et/ou au niveau d'une biomolécule d'une microparticule circulante. Les procédés comportent également des procédés de détermination de la présence, de l'absence et/ou du niveau d'une biomolécule d'une microparticule circulante à l'aide d'une sonde d'affinité à code-barres. Selon certains procédés, les biomolécules d'acide nucléique et les biomolécules non d'acide nucléique d'une microparticule circulante sont analysées ensemble. L'invention concerne également des réactifs destinés à être utilisés dans les procédés.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)