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1. (WO2020002718) NEW SUBSTITUTED N9-ADENINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AND USE THEREOF
Latest bibliographic data on file with the International BureauSubmit observation

Pub. No.: WO/2020/002718 International Application No.: PCT/ES2018/070457
Publication Date: 02.01.2020 International Filing Date: 27.06.2018
IPC:
C07D 473/34 (2006.01) ,C07F 9/38 (2006.01) ,A61K 31/52 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
473
Heterocyclic compounds containing purine ring systems
26
with an oxygen, sulfur, or nitrogen atom directly attached in position 2 or 6, but not in both
32
Nitrogen atom
34
attached in position 6, e.g. adenine
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
F
ACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9
Compounds containing elements of the 5th Group of the Periodic System
02
Phosphorus compounds
28
with one or more P-C bonds
38
Phosphonic acids (R-P(:O)(OH)2); Thiophosphonic acids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519
ortho- or peri-condensed with heterocyclic rings
52
Purines, e.g. adenine
Applicants:
SILIÓ OLIVER, Iván [ES/ES]; ES
Inventors:
SILIÓ OLIVER, Iván; ES
Agent:
CAPITÁN GARCÍA, Nuria; ES
Priority Data:
Title (EN) NEW SUBSTITUTED N9-ADENINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AND USE THEREOF
(ES) NUEVOS DERIVADOS DE ADENINA 9N SUSTITUIDOS, COMPOSICIONES FARMACÉUTICAS QUE LOS CONTIENEN Y UTILIZACIÓN DE LAS MISMAS
(FR) NOUVEAUX DÉRIVÉS D'ADÉNINE 9N SUBSTITUÉS, COMPOSITIONS PHARMACEUTIQUES LES CONTENANT ET UTILISATION DE CES DERNIÈRES
Abstract:
(EN) The invention provides new substituted N9-adenine derivatives, pharmaceutical compositions containing these derivatives and the use of the new derivatives and the pharmaceutical compositions containing same as AMPK activators, being suitable for the production of drugs for the treatment of disorders and diseases where AMPK activation plays a relevant role.
(ES) La invención proporciona nuevos derivados de adenina N9 sustituidos, composiciones farmacéuticas que incluyen estos derivados y el uso de los nuevos derivados y de las composiciones farmacéuticas que los contienen como activadores de AMPK, siendo adecuados para la producción de medicamentos destinados al tratamiento de trastornos y enfermedades donde la activación de la AMPK juega un papel relevante.
(FR) La présente invention concerne de nouveaux dérivés d'adénine N9 substitués, des compositions pharmaceutiques qui incluent ces dérivés et l'utilisation des nouveaux dérivés et des compositions pharmaceutiques qui les contiennent en tant qu'activateurs de AMPK, qui sont appropriés pour la production de médicaments destinés au traitement de troubles et de maladies pour lesquels l'activation de l'AMPK joue un rôle pertinent.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Spanish (ES)
Filing Language: Spanish (ES)