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1. (WO2020002598) BIOREACTOR FOR RNA IN VITRO TRANSCRIPTION
Latest bibliographic data on file with the International BureauSubmit observation
Pub. No.: WO/2020/002598 International Application No.: PCT/EP2019/067323
Publication Date: 02.01.2020 International Filing Date: 28.06.2019
IPC:
C12N 15/10 (2006.01) ,C12Q 1/6865 (2018.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
10
Processes for the isolation, preparation or purification of DNA or RNA
[IPC code unknown for C12Q 1/6865]
Applicants:
CUREVAC AG [DE/DE]; Paul-Ehrlich-Strasse 15 72076 Tübingen, DE
TESLA GROHMANN AUTOMATION GMBH [DE/DE]; Rudolf-Diesel-Strasse 14 54595 Prüm, DE
Inventors:
YAZDAN PANAH, Benyamin; DE
ROOS, Tilmann; DE
KUNZE, Martin; DE
BERTSCH, Felix; DE
WOCHNER, Aniela; DE
RAUEN, Michael; DE
HOFFMANN, Philipp; DE
Agent:
MAIWALD PATENTANWALTS- UND RECHTSANWALTSGESELLSCHAFT MBH; ERTL, Sophie Elisenhof, Elisenstraße 3 80335 Munich, DE
Priority Data:
PCT/EP2018/06750428.06.2018EP
Title (EN) BIOREACTOR FOR RNA IN VITRO TRANSCRIPTION
(FR) BIORÉACTEUR POUR TRANSCRIPTION IN VITRO D'ARN
Abstract:
(EN) The present invention relates to a bioreactor for RNA in vitro transcription, a method for RNA in vitro transcription, a module for transcribing DNA into RNA and an automated apparatus for RNA manufacturing. Further, the use of a bioreactor for RNA in vitro transcription as described herein is part of the present invention.The present invention relates to an RNA in vitro transcription reactor designed to be operable in an automated manner under GMP-compliant conditions. In particular, said RNA in vitro transcription reactor allows repetitive use of DNA template for various RNA in vitro transcription reactions. Further, the invention relates to an apparatus for RNA manufacturing comprising (a) a module for template DNA synthesis, (b) a module for transcribing DNA into RNA comprising said RNA in vitro transcription reactor, and, optionally, (c) a module for RNA formulation.
(FR) La présente invention concerne un bioréacteur pour la transcription in vitro d'ARN, un procédé pour la transcription in vitro d'ARN, un module pour transcrire l'ADN en ARN, et un appareil automatisé pour la fabrication d'ARN. En outre, la présente invention a trait à l'utilisation d'un bioréacteur pour la transcription in vitro d'ARN, et concerne un réacteur de transcription in vitro d'ARN conçu pour fonctionner de manière automatisée dans des conditions conformes aux bonnes pratiques de fabrication. En particulier, ledit réacteur de transcription in vitro d'ARN permet l'utilisation répétitive d'un modèle d'ADN pour diverses réactions de transcription in vitro d'ARN. En outre, l'invention concerne un appareil pour la fabrication d'ARN comprenant (a) un module pour la synthèse d'ADN de matrice, (b) un module pour transcrire l'ADN en ARN comprenant ledit réacteur de transcription in vitro d'ARN et, éventuellement, (c) un module pour la formulation d'ARN.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)