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1. WO2020002459 - POLYPEPT(O)ID-BASED GRAFT COPOLYMERS FOR IN VIVO IMAGING BY TETRAZINE TRANSCYCLOOCTENE CLICK CHEMISTRY

Publication Number WO/2020/002459
Publication Date 02.01.2020
International Application No. PCT/EP2019/067060
International Filing Date 26.06.2019
IPC
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
51
Preparations containing radioactive substances for use in therapy or testing in vivo
02
characterised by the carrier
04
Organic compounds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
51
Preparations containing radioactive substances for use in therapy or testing in vivo
02
characterised by the carrier
04
Organic compounds
08
Peptides, e.g. proteins
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
51
Preparations containing radioactive substances for use in therapy or testing in vivo
12
characterised by a special physical form, e.g. emulsion, microcapsules, liposomes
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
103
Radioactive metals
20
Indium
A61K 51/04 (2006.01)
A61K 51/08 (2006.01)
A61K 51/12 (2006.01)
A61P 35/00 (2006.01)
A61K 103/20 (2006.01)
CPC
A61K 51/0482
A61K 51/0495
A61K 51/088
A61K 51/1244
A61P 35/00
Applicants
  • RIGSHOSPITALET [DK/DK]; Blegdamsvej 9 2100 Copenhagen Ø, DK
  • JOHANNES GUTENBERG UNIVERSITY [DE/DE]; Duesburgweg 10-14 55099 Mainz, DE
  • UNIVERSITY OF COPENHAGEN [DK/DK]; Nørregade 10 1165 Copenhagen K, DK
Inventors
  • KJÆR, Andreas; DK
  • HERTH, Matthias Manfred; SE
  • BARZ, Matthias; DE
  • BIRKE, Alexander Oskar; DE
Agents
  • BUDDE SCHOU A/S; Hausergade 3 1128 Copenhagen K, DK
Priority Data
PA 2018 7045329.06.2018DK
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) POLYPEPT(O)ID-BASED GRAFT COPOLYMERS FOR IN VIVO IMAGING BY TETRAZINE TRANSCYCLOOCTENE CLICK CHEMISTRY
(FR) COPOLYMÈRES GREFFÉS À BASE DE POLYPEPT(O)IDE POUR IMAGERIE IN VIVO PAR CHIMIE CLICK DE TÉTRAZINE TRANSCYCLOOCTÈNE
Abstract
(EN)
There is provided novel polypeptide-based carrier systems, which make it possible to label polymeric nanoparticles in the living organism. This enables new approaches in tumor diagnostics (high signal to background ratio) and radiotherapy (radiotherapy of solid tumors). The polypeptide-based carrier system comprises a polypept(o)idic comb (graft) copolymer, and one or more tetrazine bioorthogonal functional groups each linked to a diagnostic agent.
(FR)
L'invention concerne de nouveaux systèmes de support à base de polypeptide, qui permettent de marquer des nanoparticules polymères dans l'organisme vivant. Ceci permet de nouvelles approches dans le diagnostic tumoral (rapport signal-fond élevé) et la radiothérapie (radiothérapie de tumeurs solides). Le système de support à base de polypeptide comprend un copolymère en peigne (greffé) polypept(o)idique, et un ou plusieurs groupes fonctionnels bioorthogonaux de tétrazine liés chacun à un agent de diagnostic.
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