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1. (WO2020002351) INHALABLE COMPOSITIONS COMPRISING MACROCYCLIC IMMUNOSUPPRESSANTS
Latest bibliographic data on file with the International BureauSubmit observation

Pub. No.: WO/2020/002351 International Application No.: PCT/EP2019/066872
Publication Date: 02.01.2020 International Filing Date: 25.06.2019
IPC:
A61K 38/13 (2006.01) ,A61K 9/00 (2006.01) ,A61K 9/127 (2006.01) ,A61P 11/00 (2006.01) ,A61P 37/06 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
04
Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
12
Cyclic peptides
13
Cyclosporins
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
10
Dispersions; Emulsions
127
Liposomes
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11
Drugs for disorders of the respiratory system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37
Drugs for immunological or allergic disorders
02
Immunomodulators
06
Immunosuppressants, e.g. drugs for graft rejection
Applicants:
BREATH THERAPEUTICS GMBH [DE/DE]; Aldringenstr. 4 80639 München, DE
Inventors:
DENK, Oliver; DE
Agent:
PHARMA PATENTS INTERNATIONAL AG; Leonhardsgraben 52 4051 Basel, CH
Priority Data:
18180177.027.06.2018EP
18210255.804.12.2018EP
Title (EN) INHALABLE COMPOSITIONS COMPRISING MACROCYCLIC IMMUNOSUPPRESSANTS
(FR) COMPOSITIONS INHALABLES COMPRENANT DES IMMUNOSUPPRESSEURS MACROCYCLIQUES
Abstract:
(EN) The present disclosure relates to a pharmaceutical composition comprising an inhalable immunosuppressive macrocyclic active ingredient for use in the prevention or treatment of a pulmonary disease or condition in a subject, wherein the pharmaceutical composition is administered to the subject by inhalation in form of an aerosol, and wherein the aerosol is generated by nebulization of the pharmaceutical composition using a nebulizer (100), the nebulizer comprising: a) an aerosol generator (101) comprising: - a fluid reservoir (103) for holding the pharmaceutical composition or an interface configured to connect a fluid reservoir, and - a vibratable membrane (110) having a plurality of apertures, the apertures being adapted to produce an aerosol comprising droplets having a mass median aerodynamic diameter (MMAD) of up to about 15 4.0 µm as measured with a 0.9 % (w/v) aqueous solution of sodium chloride; b) a chamber (105) for temporarily accommodating the aerosol generated by the aerosol generator (101), the chamber having an inner lumen with a volume in the range of from about 50 to about 150 ml; and c) a mouthpiece (40) for delivering the aerosol supplied by the nebulizer (100) to the subject, the mouthpiece having an exhalation filter (30).
(FR) La présente invention concerne une composition pharmaceutique comprenant un principe actif macrocyclique immunosuppresseur inhalable destiné à être utilisé dans la prévention ou le traitement d'une maladie ou d'un état pulmonaire chez un sujet, la composition pharmaceutique étant administrée au sujet par inhalation sous la forme d'un aérosol, et l'aérosol étant généré par nébulisation de la composition pharmaceutique à l'aide d'un nébuliseur (100), le nébuliseur comprenant : a) un générateur d'aérosol (101) comprenant : - un réservoir de fluide (103) pour contenir la composition pharmaceutique ou une interface configurée pour connecter un réservoir de fluide, et - une membrane vibrante (110) ayant une pluralité d'ouvertures, les ouvertures étant conçues pour produire un aérosol comprenant des gouttelettes ayant un diamètre aérodynamique moyen en masse (MMAD) allant jusqu'à environ 154,0 µm tel que mesuré avec une solution aqueuse à 0,9 % (w/v) de chlorure de sodium ; b) une chambre (105) pour recevoir temporairement l'aérosol généré par le générateur d'aérosol (101), la chambre ayant une lumière interne ayant un volume dans la plage d'environ 50 à environ 150 mL ; et c) un embout buccal (40) pour distribuer l'aérosol fourni par le nébuliseur (100) au sujet, l'embout buccal ayant un filtre d'expiration (30).
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)