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1. WO2020001852 - COMPOSITIONS FOR ORAL ADMINISTRATION OF PENTOSAN POLYSULFATE IN FORM OF NANOPARTICLES WITH IMPROVED INTESTINAL ABSORPTION

Publication Number WO/2020/001852
Publication Date 02.01.2020
International Application No. PCT/EP2019/062662
International Filing Date 16.05.2019
IPC
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
48
Preparations in capsules, e.g. of gelatin, of chocolate
50
Microcapsules
51
Nanocapsules
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
715
Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
716
Glucans
722
Chitin; Chitosan
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
715
Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
737
Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
[IPC code unknown for A61K 47/69]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13
Drugs for disorders of the urinary system
A61K 9/00 (2006.01)
A61K 9/51 (2006.01)
A61K 31/722 (2006.01)
A61K 31/737 (2006.01)
A61K 47/69 (2017.01)
A61P 13/00 (2006.01)
CPC
A61K 31/722
A61K 31/737
A61K 47/6939
A61K 9/0034
A61K 9/5161
A61P 13/00
Applicants
  • NEXTRARESEARCH S.R.L. [IT/IT]; Via Lorenzo Respighi, 7 00197 ROMA, IT
Inventors
  • GASPARETTO, Adolfo; IT
  • BORELLA, Fabio; IT
  • MASCILONGO, Viviana; IT
  • BETTINI, Ruggero; IT
  • SONVICO, Fabio; IT
  • CITO, Marta; IT
Agents
  • MINOJA, Fabrizio; IT
Priority Data
18180223.227.06.2018EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) COMPOSITIONS FOR ORAL ADMINISTRATION OF PENTOSAN POLYSULFATE IN FORM OF NANOPARTICLES WITH IMPROVED INTESTINAL ABSORPTION
(FR) COMPOSITIONS POUR L'ADMINISTRATION ORALE DE POLYSULFATE DE PENTOSANE SOUS FORME DE NANOPARTICULES À ABSORPTION INTESTINALE AMÉLIORÉE
Abstract
(EN)
The present invention relates to pharmaceutical composition for the oral delivery of Pentosan Polysulfate sodium (PPS). In particular, the invention discloses compositions of PPS in form of nanoparticles with a suitable polymer aimed to improve the PPS absorption in the small intestine and reduce or eliminate the side effects in the colon.
(FR)
La présente invention concerne une composition pharmaceutique pour l'administration orale de pentosane polysulfate de sodium (PPS). En particulier, l'invention concerne des compositions de PPS sous forme de nanoparticules avec un polymère approprié visant à améliorer l'absorption de PPS dans l'intestin grêle et à réduire ou éliminer les effets secondaires dans le côlon.
Latest bibliographic data on file with the International Bureau