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1. WO2020001548 - SALT, CRYSTAL FORM AND PHARMACEUTICAL COMPOSITION OF 3-ALKENYL INDOLONE COMPOUND, AND USE THEREOF

Publication Number WO/2020/001548
Publication Date 02.01.2020
International Application No. PCT/CN2019/093308
International Filing Date 27.06.2019
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
209
Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
02
condensed with one carbocyclic ring
04
Indoles; Hydrogenated indoles
30
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
32
Oxygen atoms
34
in position 2
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
40
having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
403
condensed with carbocyclic rings, e.g. carbazole
404
Indoles, e.g. pindolol
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
C07D 209/34 (2006.01)
A61K 31/404 (2006.01)
A61P 3/00 (2006.01)
CPC
A61K 31/404
A61P 13/12
A61P 3/00
A61P 3/06
A61P 3/10
A61P 9/10
Applicants
  • 中国科学院上海药物研究所 SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES [CN/CN]; 中国上海市 浦东张江祖冲之路555号 555 Zu Chong Zhi Road Zhang Jiang, Pudong Shanghai 201203, CN
Inventors
  • 南发俊 NAN, Fajun; CN
  • 李静雅 LI, Jingya; CN
  • 张仰明 ZHANG, Yangming; CN
  • 李佳 LI, Jia; CN
  • 谢志富 XIE, Zhifu; CN
  • 张梅 ZHANG, Mei; CN
  • 崔世超 CUI, Shichao; CN
  • 顾民 GU, Min; CN
  • 马辉 MA, Hui; CN
  • 虞燕燕 YU, Yanyan; CN
  • 刘桦楠 LIU, Huanan; CN
Agents
  • 上海一平知识产权代理有限公司 XU & PARTNERS, LLC.; 中国上海市 普陀区真北路958号天地科技广场1号楼106室 Room 106, Building No. 1 Universal High-Tech Plaza 958 Zhen Bei Road, Putuo District Shanghai 200333, CN
Priority Data
201810688793.928.06.2018CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) SALT, CRYSTAL FORM AND PHARMACEUTICAL COMPOSITION OF 3-ALKENYL INDOLONE COMPOUND, AND USE THEREOF
(FR) SEL, FORME CRISTALLINE ET COMPOSITION PHARMACEUTIQUE DE COMPOSÉ 3-ALCÉNYLE INDOLONE, ET UTILISATION ASSOCIÉE
(ZH) 3-烯基吲哚酮类化合物的盐、其晶型、其药物组合物及其用途
Abstract
(EN)
The present invention relates to a salt, a crystal form and a pharmaceutical composition of a 3-alkenyl indolone compound, and the use thereof. Specifically, compared with the compound, the salt form of the compound has better water solubility, and is accordingly more conducive to subsequent drug development. In addition, the salt form of the compound has better in vivo metabolic properties.
(FR)
La présente invention concerne un sel, une forme cristalline et une composition pharmaceutique d'un composé 3-alcényl-indolone, et une utilisation associée. En particulier, par comparaison avec le composé, la forme de sel du composé a une meilleure solubilité dans l'eau, et est par conséquent plus appropriée au développement du médicament dans l'avenir. De plus, la forme de sel du composé présente de meilleures propriétés métaboliques in vivo.
(ZH)
涉及3-烯基吲哚酮类化合物的盐、其晶型、其药物组合物及其用途。具体地,相比于化合物,该化合物的盐型具有更优的水溶解性,因而更利于后续的药物开发。此外,该类化合物的盐型具有更优的体内代谢特性。
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