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1. WO2020001449 - ISOTHIAZOLO[5,4-D]PYRIMIDINE COMPOUND AS IRAK4 INHIBITOR

Publication Number WO/2020/001449
Publication Date 02.01.2020
International Application No. PCT/CN2019/092867
International Filing Date 25.06.2019
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
417
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
14
containing three or more hetero rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519
ortho- or peri-condensed with heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
535
having six-membered rings with at least one nitrogen and at least one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
5375
1,4-Oxazines, e.g. morpholine
5377
not condensed and containing further heterocyclic rings, e.g. timolol
C07D 417/14 (2006.01)
A61K 31/519 (2006.01)
A61K 31/5377 (2006.01)
CPC
A61K 31/519
A61K 31/5377
C07D 417/14
Applicants
  • 南京明德新药研发有限公司 MEDSHINE DISCOVERY INC. [CN/CN]; 中国江苏省南京市 南京高新开发区高新路9号商务办公室218室 Room 218, No.9 Gaoxin Road, Gaoxin Development District Nanjing, Jiangsu 210032, CN
Inventors
  • 张杨 ZHANG, Yang; CN
  • 王建非 WANG, Jianfei; CN
  • 谭海忠 TAN, Haizhong; CN
  • 李婕 LI, Jie; CN
  • 黎健 LI, Jian; CN
  • 陈曙辉 CHEN, Shuhui; CN
Agents
  • 上海弼兴律师事务所 SHANGHAI BESHINING LAW OFFICE; 中国上海市 小木桥路681号外经大厦21楼 21st Floor, SFECO Mansion 681 Xiaomuqiao Road Shanghai 200032, CN
Priority Data
201810662580.925.06.2018CN
201910463156.630.05.2019CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) ISOTHIAZOLO[5,4-D]PYRIMIDINE COMPOUND AS IRAK4 INHIBITOR
(FR) COMPOSÉ D'ISOTHIAZOLO [5,4-D] PYRIMIDINE EN TANT QU'INHIBITEUR D'IRAK
(ZH) 作为IRAK4抑制剂的异噻唑并[5,4-d]嘧啶类化合物
Abstract
(EN)
Disclosed in the present invention are an IRAK4 inhibitor, and an application thereof in preparation of a drug for treating IRAK4-related diseases. Specifically disclosed are a compound represented by formula (III) and a pharmaceutically acceptable salt thereof.
(FR)
La présente invention concerne un inhibiteur d'IRAK4, et une application de celui-ci dans la préparation D'un médicament pour le traitement de maladies associées à IRAK4. L'invention concerne spécifiquement un composé représenté par la formule (III) et un sel pharmaceutiquement acceptable de celui-ci.
(ZH)
本发公开了一类IRAK4抑制剂,及其在制备治疗与IRAK4相关疾病的药物中的应用。具体公开了式(Ⅲ)所示化合物及其药学上可接受的盐。
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