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1. WO2020001203 - COMPOUND AMINO ACID VITAMIN INJECTION SOLUTION AND USE THEREOF

Publication Number WO/2020/001203
Publication Date 02.01.2020
International Application No. PCT/CN2019/087884
International Filing Date 22.05.2019
IPC
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
04
Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
05
Dipeptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
08
Solutions
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
02
Nutrients, e.g. vitamins, minerals
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37
Drugs for immunological or allergic disorders
02
Immunomodulators
04
Immunostimulants
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
39
General protective or antinoxious agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
185
Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19
Carboxylic acids, e.g. valproic acid
195
having an amino group
197
the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid (GABA), beta-alanine, epsilon-aminocaproic acid, pantothenic acid
198
Alpha-amino acids, e.g. alanine, edetic acid (EDTA)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
40
having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
403
condensed with carbocyclic rings, e.g. carbazole
404
Indoles, e.g. pindolol
405
Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4164
1,3-Diazoles
4172
Imidazole-alkanecarboxylic acids, e.g. histidine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
4415
Pyridoxine, i.e.vitamin B6
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
506
not condensed and containing further heterocyclic rings
51
Thiamines, e.g. vitamin B1
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7135
Compounds containing heavy metals
714
Cobalamins, e.g. cyanocobalamin, vitamin B12
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33
Medicinal preparations containing inorganic active ingredients
04
Sulfur, selenium or tellurium; Compounds thereof
A61K 38/05 (2006.01)
A61K 9/08 (2006.01)
A61P 3/02 (2006.01)
A61P 37/04 (2006.01)
A61P 39/00 (2006.01)
A61K 31/198 (2006.01)
CPC
A61K 31/198
A61K 31/405
A61K 31/4172
A61K 31/4415
A61K 31/51
A61K 31/714
Applicants
  • 复旦大学附属中山医院 ZHONGSHAN HOSPITAL FUDAN UNIVESITY [CN/CN]; 中国上海市 徐汇区枫林路180号 No. 180 Fenglin Road, Xuhui Shanghai 200032, CN
Inventors
  • 葛圣金 GE, Shengjin; CN
Agents
  • 上海申汇专利代理有限公司 SHANGHAI SHENHUI PATENT AGENT CO., LTD.; 中国上海市 徐汇区漕宝路80号405室 Room 405, No.80 Caobao Road Xuhui District, Shanghai 200235, CN
Priority Data
201810694065.929.06.2018CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) COMPOUND AMINO ACID VITAMIN INJECTION SOLUTION AND USE THEREOF
(FR) SOLUTION D'INJECTION DE VITAMINE D'ACIDE AMINÉ COMPOSÉE ET SON UTILISATION
(ZH) 一种复方氨基酸维生素注射液及其应用
Abstract
(EN)
Disclosed in the present invention are a compound amino acid vitamin injection solution and use thereof. The compound amino acid vitamin injection solution comprises per 1000 ml: 5-40 g of L-leucine, 2-30 g of L-isoleucine, 2-30 g of L-valine, 5-90 g of L-alanyl-L-glutamine, 1-5 g of L-threonine, 1-10 g of L-lysine, 1-12 g of L-methionine, 1-10 g of L-phenylalanine, 0.5-8 g of L-tryptophan, 2-30 g of L-arginine, 1-10 g of L-histidine, 1-100 mg of Vitamin B6, 0-50 mg of vitamin B1, and 0-100 μg of vitamin B12. The present invention is directed to changes of stress, immunization, metabolism or the like in human perioperative period, and achieves the purpose of inhibiting catabolism, promoting anabolism, producing heat and keeping warm, improving energy metabolism of substances and body immunity, and helping rehabilitation.
(FR)
La présente invention concerne une solution d'injection de vitamine d'acide aminé composée et son utilisation. La solution d'injection de vitamine d'acide aminé composée comprend pour 1000 mL : 5 à 40 g de L-leucine, 2 à 30 g de L-isoleucine, 2 à 30 g de L-valine, 5 à 90 g de L-alanyl-L-glutamine, 1 à 5 g de L-thréonine, 1-10 g de L-lysine, 1 à 12 g de L-méthionine, 1 à 10 g de L-phénylalanine, 0,5 à 8 g de L-tryptophane, 2 à 30 g de L-arginine, 1 à 10 g de L-histidine, 1 à 100 mg de vitamine B6, 0 à 50 mg de vitamine B1, et 0 à 100 μg de vitamine B12. La présente invention concerne des changements de stress, d'immunisation, de métabolisme ou similaires dans une période périopératoire humaine, et permet d'inhiber le catabolisme, de favoriser l'anabolisme, de produire de la chaleur et de maintenir la chaleur, d'améliorer le métabolisme énergétique des substances et l'immunité du corps, et d'aider à la rééducation.
(ZH)
本发明公开一种复方氨基酸维生素注射液及其应用,每1000ml中含:L-亮氨酸:5-40g、L-异亮氨酸:2-30g、L-缬氨酸:2-30g、L-丙氨酰-L-谷氨酰胺:5-90g、L-苏氨酸:1-5g、L-赖氨酸:1-10g、L-蛋氨酸:1-12g、L-苯丙氨酸:1-10g、L-色氨酸:0.5-8g、L-精氨酸:2-30g、L-组氨酸:1-10g、维生素B6:1-100mg、维生素B1:0-50mg、维生素B12:0-100μg。本发明针对人体围手术麻醉期应激、免疫、代谢等的变化,起到抑制分解代谢、促进合成代谢,产热保温,改善机体物质能量代谢和免疫功能,帮助康复的目的。
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