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1. WO2020000555 - METHOD FOR PREPARING TERIPARATIDE

Publication Number WO/2020/000555
Publication Date 02.01.2020
International Application No. PCT/CN2018/097403
International Filing Date 27.07.2018
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
575
Hormones
635
Parathyroid hormone (parathormone); Parathyroid hormone-related peptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
1
General processes for the preparation of peptides
06
using protecting groups or activating agents
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
1
General processes for the preparation of peptides
04
on carriers
C07K 14/635 (2006.01)
C07K 1/06 (2006.01)
C07K 1/04 (2006.01)
CPC
C07K 1/04
C07K 1/06
C07K 1/14
C07K 14/635
Applicants
  • 深圳翰宇药业股份有限公司 HYBIO PHARMACEUTICAL CO., LTD. [CN/CN]; 中国广东省深圳市 南山区高新技术工业园中区翰宇生物医药园办公大楼四层 4th Floor of Office Building Hybio Medicine Park, Shenzhen Hi-tech Industrial Park, Nanshan District Shenzhen, Guangdong 518057, CN
Inventors
  • 汪伟 WANG, Wei; CN
  • 宓鹏程 MI, Pengcheng; CN
  • 陶安进 TAO, Anjin; CN
  • 袁建成 YUAN, Jiancheng; CN
Agents
  • 深圳市深佳知识产权代理事务所(普通合伙) SHENPAT INTELLECTUAL PROPERTY AGENCY; 中国广东省深圳市罗湖区南湖街道春风路庐山大厦B座18C2、18D、18E、18E2 18C2, 18D, 18E, 18E2 Block B, Lushan Building Chunfeng Road, Nanhu Street, Luohu District Shenzhen, Guangdong 518001, CN
Priority Data
201810671869.726.06.2018CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) METHOD FOR PREPARING TERIPARATIDE
(FR) PROCÉDÉ DE PRÉPARATION DE TÉRIPARATIDE
(ZH) 一种制备特立帕肽的方法
Abstract
(EN)
The invention belongs to the technical field of pharmaceutical chemistry, in which a method for preparing teriparatide is disclosed. First, peptide sequences 1-16 (fragment A) and peptide sequences 17-34 (fragment B) of teriparatide are separately synthesized, and then the two fragments are coupled to obtain a teriparatide crude peptide, which is then purified to obtain teriparatide. The teriparatide product obtained by the present invention has high purity and is easily purified.
(FR)
L'invention concerne le domaine technique de la chimie pharmaceutique, un procédé de préparation de tériparatide étant décrit. D'abord, les séquences peptidiques 1-16 (fragment A) et les séquences peptidiques 17-34 (fragment B) de tériparatide sont synthétisées séparément, puis les deux fragments sont couplés pour obtenir un peptide brut de tériparatide, qui est ensuite purifié pour obtenir du tériparatide. Le produit de tériparatide obtenu selon la présente invention possède une pureté élevée et est facilement purifié.
(ZH)
本发明属于药物化学技术领域,公开了一种制备特立帕肽的方法。首先分别合成特立帕肽第1-16位肽序列(片段A)和第17-34位肽序列(片段B),然后,将两个片段偶联得到特立帕肽粗肽,纯化获得特立帕肽。本发明得到的特立帕肽产品纯度高,易于纯化。
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