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1. WO2020000526 - SHP-1-KNOCKOUT T-CELL AND CONSTRUCTION METHOD THEREFOR

Publication Number WO/2020/000526
Publication Date 02.01.2020
International Application No. PCT/CN2018/095635
International Filing Date 13.07.2018
IPC
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
10
Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79
Vectors or expression systems specially adapted for eukaryotic hosts
85
for animal cells
C12N 5/10 (2006.01)
C12N 15/85 (2006.01)
CPC
C07K 14/47
C12N 15/85
C12N 2510/00
C12N 2800/80
C12N 2810/10
C12N 5/0636
Applicants
  • 奥妙生物技术(广州)有限公司 AOMIAO BIOTECHNOLOGY (GUANGZHOU) CO., LTD. [CN/CN]; 中国广东省广州市 广州经济技术开发区科学城开源大道188号 No. 188, Kaiyuan Avenue, Science City Guangzhou Economic and Technological Development Zone Guangzhou, Guangdong 510000, CN
Inventors
  • 胡边 HU, Bian; CN
  • 张琳琳 ZHANG, Linlin; CN
Agents
  • 广州嘉权专利商标事务所有限公司 JIAQUAN IP LAW FIRM; 中国广东省广州市 天河区黄埔大道西100号富力盈泰广场A栋910张萍 ZHANG, Ping No. 910, Building A, Winner Plaza, No.100 West Huangpu Avenue, Tianhe District Guangzhou, Guangdong 510627, CN
Priority Data
201810665548.626.06.2018CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) SHP-1-KNOCKOUT T-CELL AND CONSTRUCTION METHOD THEREFOR
(FR) LYMPHOCYTE T SHP-1-INACTIVÉ ET PROCÉDÉ DE CONSTRUCTION ASSOCIÉ
(ZH) SHP-1敲除的T细胞及其构建方法
Abstract
(EN)
Provided are an SHP-1-knockout T-cell and a construction method therefor. The killing effect of the T-cell on tumors can be effectively improved by the endogenous blockade of SHP-1 in the T-cell, thereby providing a new target for tumor immunotherapy.
(FR)
La présente invention concerne un lymphocyte t SHP-1-inactivé et un procédé de construction associé L'effet destructeur du lymphocyte T sur des tumeurs peut être efficacement amélioré par le blocage endogène de SHP -1 dans le lymphocyte T, fournissant ainsi une nouvelle cible pour l'immunothérapie antitumorale.
(ZH)
提供了SHP-1敲除的T细胞及其构建方法。通过将T细胞中的SHP-1内源性阻断,可以有效提高T细胞对肿瘤的杀伤作用,为肿瘤免疫疗法提供了新的靶点。
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