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1. WO2020000458 - GRNA TARGETING SEQUENCE FOR SPECIFICALLY TARGETING HUMAN NGL GENE AND APPLICATION THEREOF

Publication Number WO/2020/000458
Publication Date 02.01.2020
International Application No. PCT/CN2018/093868
International Filing Date 29.06.2018
IPC
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
113
Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79
Vectors or expression systems specially adapted for eukaryotic hosts
85
for animal cells
C12N 15/113 (2010.01)
C12N 15/85 (2006.01)
CPC
C12N 15/113
C12N 15/85
Applicants
  • 深圳市博奥康生物科技有限公司 SHENZHEN BIOCAN TECHNOLOGIES CO., LTD. [CN/CN]; 中国广东省深圳市 南山区西丽街道珠光路134号珠光创新科技园1栋509室 毛吉炎 MAO Jiyan Room 509, Building 1, Zhuguang Innovation Park No.134 Zhuguang Road, Xilii Street, Nanshan District Shenzhen, Guangdong 518055, CN
Inventors
  • 毛吉炎 MAO, Jiyan; CN
Priority Data
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) GRNA TARGETING SEQUENCE FOR SPECIFICALLY TARGETING HUMAN NGL GENE AND APPLICATION THEREOF
(FR) SÉQUENCE DE CIBLAGE D'ARNG POUR LE CIBLAGE SPÉCIFIQUE DU GÈNE NFL HUMAIN ET SON APPLICATION
(ZH) 一种特异靶向人NGL基因的gRNA导向序列及其应用
Abstract
(EN)
Provided is a gRNA targeting sequence for specifically targeting human NGL gene, which has a nucleotide sequence of 5'-AGCTGAGATTCCCCTCCATT-3'. Knockout of the NGL gene is achieved after introducing the gRNA and the CRISPR system into the target cell by the Cas9 carrier.
(FR)
L'invention concerne une séquence de ciblage d'ARNg pour le ciblage spécifique du gène NGL humain, qui a une séquence nucléotidique 5'-AGCTGAGATTCCCCTCCATT-3'. L'inactivation du gène NGL est obtenue après l'introduction de l'ARNg et du système CRISPR dans la cellule cible par le support Cas9.
(ZH)
一种特异靶向人NGL基因的gRNA导向序列,该gRNA导向序列的核苷酸序列为5'-AGCTGAGATTCCCCTCCATT-3'。利用Cas9载体将该gRNA以及CRISPR系统引入目标细胞后,实现NGL基因的敲除。
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