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1. (WO2020000453) NOVEL HUMAN INDO GENE-TARGETED RNAI INTERFERENCE FRAGMENT, RNAI CARRIER AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Latest bibliographic data on file with the International BureauSubmit observation

Pub. No.: WO/2020/000453 International Application No.: PCT/CN2018/093863
Publication Date: 02.01.2020 International Filing Date: 29.06.2018
IPC:
C12N 15/113 (2010.01) ,C12N 15/66 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
113
Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
66
General methods for inserting a gene into a vector to form a recombinant vector using cleavage and ligation; Use of non-functional linkers or adaptors, e.g. linkers containing the sequence for a restriction endonuclease
Applicants:
深圳市博奥康生物科技有限公司 SHENZHEN BIOCAN TECHNOLOGIES CO., LTD. [CN/CN]; 中国广东省深圳市 南山区西丽街道珠光路134号珠光创新科技园1栋509室 毛吉炎 MAO, Jiyan Room 509, Building 1, Zhuguang Innovation Park No.134 Zhuguang Road, Xilii Street, Nanshan District Shenzhen, Guangdong 518055, CN
Inventors:
毛吉炎 MAO, Jiyan; CN
Priority Data:
Title (EN) NOVEL HUMAN INDO GENE-TARGETED RNAI INTERFERENCE FRAGMENT, RNAI CARRIER AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
(FR) NOUVEAU FRAGMENT D'INTERFÉRENCE D'ARNI CIBLANT LE GÈNE INDO HUMAIN, SUPPORT D'ARNI ET SON PROCÉDÉ DE PRÉPARATION ET APPLICATION CORRESPONDANTE
(ZH) 一种靶向人 INDO 基因的新型 RNAi 干扰片段、 RNAi 载体及其制备方法和其应用
Abstract:
(EN) A novel human INDO gene-targeted RNAi interference fragment, a carrier comprising the RNAi, and a preparation method therefor and an application thereof. The RNAi interference fragment is as shown in SEQ ID NO.1, and can guide LwCas13a to perform accurate identification and cutting on mRNA formed by transcribing the human INDO gene to achieve specific expression interference of the INDO gene.
(FR) L'invention concerne un nouveau fragment d'interférence d'ARNi ciblant le gène INDO humain, un support comprenant l'ARNi, et son procédé de préparation et une application correspondante. Le fragment d'interférence d'ARNi est tel que présenté dans SEQ ID NO.1, et peut guider LwCas13a pour effectuer une identification et une coupe précises sur l'ARNm formé par transcription du gène INDO humain pour obtenir une interférence d'expression spécifique du gène INDO.
(ZH) 一种靶向人INDO基因的RNAi干扰片段、包含该RNAi的载体及其制备方法和其应用。该RNAi干扰片段如SEQ ID NO.1所示,可引导LwCas13a对人INDO基因转录形成的mRNA进行精准的识别与切割,实现对INDO基因的特异性表达干扰。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)