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1. WO2020000035 - MODIFIED T CELLS AND USES THEREOF

Publication Number WO/2020/000035
Publication Date 02.01.2020
International Application No. PCT/AU2019/050660
International Filing Date 25.06.2019
IPC
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
071
Vertebrate cells or tissues, e.g. human cells or tissues
078
Cells from blood or from the immune system
0783
T cells; NK cells; Progenitors of T or NK cells
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79
Vectors or expression systems specially adapted for eukaryotic hosts
85
for animal cells
[IPC code unknown for A61K 35/17]
C12N 5/0783 (2010.01)
C12N 15/85 (2006.01)
A61K 35/17 (2015.01)
CPC
A61K 2039/5158
A61K 35/17
A61K 38/2013
A61K 39/001102
A61K 39/39558
A61K 47/6425
Applicants
  • PETER MACCALLUM CANCER INSTITUTE [AU/AU]; 305 Grattan Street Melbourne, Victoria 3000, AU
Inventors
  • BEAVIS, Paul; AU
  • DARCY, Philip; AU
Agents
  • DAVIES COLLISON CAVE; 1 Nicholson Street Melbourne, Victoria 3000, AU
Priority Data
201890226025.06.2018AU
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) MODIFIED T CELLS AND USES THEREOF
(FR) LYMPHOCYTES T MODIFIÉS ET LEURS UTILISATIONS
Abstract
(EN)
The present invention generally relates to T cells that are modified to enhance the efficiency of adoptive cellular therapy by modulating dendritic cell activity, a composition comprising modified T cells, vectors and methods for the treatment of cancer comprising administering modified T cells. In particular, the present invention provides modified T cells for use in adoptive cellular therapies for the treatment of solid tumours.
(FR)
La présente invention concerne de manière générale des lymphocytes T qui sont modifiés pour améliorer l'efficacité de la thérapie cellulaire adoptive par modulation de l'activité des cellules dendritiques, une composition comprenant des lymphocytes T modifiés, des vecteurs et des procédés pour le traitement du cancer comprenant l'administration de lymphocytes T modifiés. En particulier, la présente invention concerne des lymphocytes T modifiés destinés à être utilisés dans des thérapies cellulaires adoptives pour le traitement de tumeurs solides.
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