WO2019234761 AN IMPROVED PROCESS FOR THE PREPARATION OF CABOZANTINIB AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF

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Publication Number WO/2019/234761

Publication Date 12.12.2019

International Application No. PCT/IN2019/050432

International Filing Date 04.06.2019

IPC

CPC

Applicants

NATCO PHARMA LIMITED [IN]/[IN]

Inventors

AMALA, Kompella
VENUGOPALA KRISHNA, Gampa
ANKAMANAYUDU, Annadasu
SRINIVASULU, Ganganamoni
DURGA PRASAD, Konakanchi
PULLA REDDY, Muddasani
VENKAIAH CHOWDARY, Nannapaneni

Priority Data

201841021025

05.06.2018

Publication Language English (en)

Filing Language English (EN)

Designated States

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Title

(EN) AN IMPROVED PROCESS FOR THE PREPARATION OF CABOZANTINIB AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF

(FR) PROCÉDÉ AMÉLIORÉ POUR LA PRÉPARATION DE CABOZANTINIB ET DE SES SELS PHARMACEUTIQUEMENT ACCEPTABLES

Abstract

(EN) The present invention relates to an improved process for the preparation of N-(4-(6,7-dimethoxyquinolin-4-yloxy)phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide compound of formula-1 which is represented by the following structural formula:

(FR) La présente invention concerne un procédé amélioré pour la préparation d'un composé de N-(4-(6,7-diméthoxyquinolin-4-yloxy)phényl)-N'-(4-fluorophényl)cyclopropane-1,1-dicarboxamide de formule -1 qui est représenté par la formule structurale suivante :

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
395	having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435	having six-membered rings with one nitrogen as the only ring hetero atom
47	Quinolines; Isoquinolines

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
395	having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435	having six-membered rings with one nitrogen as the only ring hetero atom
47	Quinolines; Isoquinolines

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
B	GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
2200	Indexing scheme relating to specific properties of organic compounds
13	Crystalline forms, e.g. polymorphs

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
C	ACYCLIC OR CARBOCYCLIC COMPOUNDS
231	Preparation of carboxylic acid amides
12	by reactions not involving the formation of carboxamide groups

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
215	Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
02	having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
16	with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
20	Oxygen atoms
22	attached in position 2 or 4
233	only one oxygen atom which is attached in position 4

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1. WO2019234761 - AN IMPROVED PROCESS FOR THE PREPARATION OF CABOZANTINIB AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF