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1. WO2019234761 - AN IMPROVED PROCESS FOR THE PREPARATION OF CABOZANTINIB AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF

Publication Number WO/2019/234761
Publication Date 12.12.2019
International Application No. PCT/IN2019/050432
International Filing Date 04.06.2019
IPC
A61K 31/47 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
C07K 2317/33
CPC
C07B 2200/13
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
2200Indexing scheme relating to specific properties of organic compounds
13Crystalline forms, e.g. polymorphs
C07C 231/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
231Preparation of carboxylic acid amides
12by reactions not involving the formation of carboxamide groups
C07D 215/233
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
215Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
02having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
16with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
20Oxygen atoms
22attached in position 2 or 4
233only one oxygen atom which is attached in position 4
Applicants
  • NATCO PHARMA LIMITED [IN]/[IN]
Inventors
  • AMALA, Kompella
  • VENUGOPALA KRISHNA, Gampa
  • ANKAMANAYUDU, Annadasu
  • SRINIVASULU, Ganganamoni
  • DURGA PRASAD, Konakanchi
  • PULLA REDDY, Muddasani
  • VENKAIAH CHOWDARY, Nannapaneni
Priority Data
20184102102505.06.2018IN
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) AN IMPROVED PROCESS FOR THE PREPARATION OF CABOZANTINIB AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF
(FR) PROCÉDÉ AMÉLIORÉ POUR LA PRÉPARATION DE CABOZANTINIB ET DE SES SELS PHARMACEUTIQUEMENT ACCEPTABLES
Abstract
(EN) The present invention relates to an improved process for the preparation of N-(4-(6,7-dimethoxyquinolin-4-yloxy)phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide compound of formula-1 which is represented by the following structural formula:
(FR) La présente invention concerne un procédé amélioré pour la préparation d'un composé de N-(4-(6,7-diméthoxyquinolin-4-yloxy)phényl)-N'-(4-fluorophényl)cyclopropane-1,1-dicarboxamide de formule -1 qui est représenté par la formule structurale suivante :
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