WO2019227085 DESIGNED BACTERIAL COMPOSITIONS AND USES THEREOF

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Publication Number WO/2019/227085

Publication Date 28.11.2019

International Application No. PCT/US2019/034069

International Filing Date 24.05.2019

IPC

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Applicants

SERES THERAPEUTICS, INC. [US]/[US]

Inventors

MARTINEZ, Asuncion
O'BRIEN, Edward J.
SIMMONS, Sheri Lynn
COOK, David
HENN, Matthew R.
FORD, Christopher B.
BALASUBRAMANIAN, Divya
PIÑA, Ambar
DIAO, Liyang
CHAFEE, Meghan
VULIC, Marin
NANDAKUMAR, Madhumitha
DATTA, Sumon
JAYARAMAN, Latta

Agents

FRUEAUF, Jeremiah B.
BANOWIT, Donald R.
BEZOS, Salvador M.
BODENSTEIN, Matthew S.
CALVO, Paul A.
CAMARCE, Christian
CIMBALA, Michelle A.
COLLER III, Richard D.
CONKLIN, Kyle E.
CORNWELL, David K.S.
COVERT, John M.
DESAI, Nirav N.
DURKIN, Tracy-Gene G.
EISENBERG, Jason D.
ELLISON, Eldora L.
ESMOND, Robert W.
FEATHERSTONE, Donald J.
GAJEWSKI, Daniel
GILLENTINE, Marsha Rose
GOLDSTEIN, Jorge A.
HELVEY, Jeffrey T.
HICKS, Ross G.
HOLOUBEK, Michelle K.
JACKMAN, Peter A.
KIM, Ji-Eun
LEE, Michael Q.
LONGSWORTH, Gaby L.
MILLONIG, Robert C.
MUTSCHELKNAUS, Joseph E.
NANNENGA-COMBS, Bonnie
PHERO, Graham
PICKARD, Byron L.
POWERS, III, R. Wilson
RAY, Michael B.
RYGIEL, Mark W.
SHEA, JR, Timothy J.
SOKOHL, Robert E.
SPECHT, Michael D.
STEFFE, Eric K.
STERLING, Deborah A.
STERNE, Robert Greene
TUMINARO, Jonathan
WRIGHT, Jon E.
YONAN, Daniel E.

Priority Data

62/676,236

24.05.2018

Publication Language English (en)

Filing Language English (EN)

Designated States

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Title

(EN) DESIGNED BACTERIAL COMPOSITIONS AND USES THEREOF

(FR) COMPOSITIONS BACTÉRIENNES CONÇUES ET LEURS UTILISATIONS

Abstract

(EN) Provided herein are bacterial compositions that are useful for treating and preventing complications and side effects associated with a disease or disorder, such as those associated with dysbiosis of a gastrointestinal tract. The bacterial compositions disclosed herein are designed to exhibit one or more functional features that are useful for the treatment of such diseases and disorders.

(FR) L'invention concerne des compositions bactériennes qui sont utiles pour traiter et pour prévenir des complications ainsi que des effets secondaires associés à une maladie ou à un trouble tels que celles et ceux associé(e)s à une dysbiose du tube digestif. Les compositions bactériennes ici divulguées sont conçues pour présenter une ou plusieurs caractéristiques qui sont utiles dans le traitement de telles maladies et de tels troubles.

A	HUMAN NECESSITIES
23	FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
L	FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D91; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
33	Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
10	using additives
135	Bacteria or derivatives thereof, e.g. probiotics

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35	Medicinal preparations containing materials or reaction products thereof with undetermined constitution
66	Microorganisms or materials therefrom
74	Bacteria

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35	Medicinal preparations containing materials or reaction products thereof with undetermined constitution
66	Microorganisms or materials therefrom
74	Bacteria
741	Probiotics

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35	Medicinal preparations containing materials or reaction products thereof with undetermined constitution
66	Microorganisms or materials therefrom
74	Bacteria
741	Probiotics
742	Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1	Drugs for disorders of the alimentary tract or the digestive system

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1. WO2019227085 - DESIGNED BACTERIAL COMPOSITIONS AND USES THEREOF

C	CHEMISTRY; METALLURGY
12	BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N	MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1	Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
20	Bacteria; Culture media therefor

A	HUMAN NECESSITIES
23	FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
L	FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A23B - A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT
33	Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
10	using additives
135	Bacteria or derivatives thereof, e.g. probiotics

A	HUMAN NECESSITIES
23	FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
V	INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES
2002	Food compositions, function of food ingredients or processes for food or foodstuffs

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38	Medicinal preparations containing peptides
16	Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17	from animals; from humans
18	Growth factors; Growth regulators

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47	Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06	Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
08	containing oxygen, ; e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
10	Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47	Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06	Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
26	Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9	Medicinal preparations characterised by special physical form
14	Particulate form, e.g. powders, ; Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
19	lyophilised ; , i.e. freeze-dried, solutions or dispersions