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1. (WO2019227063) METHODS, ASSAYS, AND KITS FOR EVALUATING THE PERFORMANCE OF ENGINEERED LIVER TISSUE CONSTRUCTS
Latest bibliographic data on file with the International BureauSubmit observation

Pub. No.: WO/2019/227063 International Application No.: PCT/US2019/034031
Publication Date: 28.11.2019 International Filing Date: 24.05.2019
IPC:
A61B 10/00 (2006.01) ,A61B 5/15 (2006.01) ,C12Q 1/68 (2018.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
B
DIAGNOSIS; SURGERY; IDENTIFICATION
10
Other methods or instruments for diagnosis, e.g. for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
B
DIAGNOSIS; SURGERY; IDENTIFICATION
5
Measuring for diagnostic purposes; Identification of persons
15
Devices for taking samples of blood
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
Applicants:
ORGANOVO, INC. [US/US]; 6275 Nancy Ridge Drive, Suite 110 San Diego, California 92121, US
Inventors:
DAVIS, Scott; US
PRESNELL, Sharon C.; US
Agent:
STERLING, Deborah A.; US
BANOWIT, Donald R.; US
BEZOS, Salvador M.; US
BODENSTEIN, Matthew S.; US
CALVO, Paul A.; US
CAMARCE, Christian; US
CIMBALA, Michelle A.; US
COLLER III, Richard D.; US
CONKLIN, Kyle E.; US
CORNWELL, David K.S.; US
COVERT, John M.; US
DESAI, Nirav N.; US
DURKIN, Tracy-Gene G.; US
EISENBERG, Jason D.; US
ELLISON, Eldora L.; US
ESMOND, Robert W.; US
FEATHERSTONE, Donald J.; US
FRUEAUF, Jeremiah B.; US
GAJEWSKI, Daniel; US
GILLENTINE, Marsha Rose; US
GOLDSTEIN, Jorge A.; US
HELVEY, Jeffrey T.; US
HICKS, Ross G.; US
HOLOUBEK, Michelle K.; US
JACKMAN, Peter A.; US
KIM, Ji-Eun; US
LEE, Michael Q.; US
LONGSWORTH, Gaby L.; US
MILLONIG, Robert C.; US
MUTSCHELKNAUS, Joseph E.; US
NANNENGA-COMBS, Bonnie; US
PHERO, Graham; US
PICKARD, Byron L.; US
POWERS, III, R. Wilson; US
RAY, Michael B.; US
RYGIEL, Mark W.; US
SHEA, JR, Timothy J.; US
SOKOHL, Robert E.; US
SPECHT, Michael D.; US
STEFFE, Eric K.; US
STERNE, Robert Greene; US
TUMINARO, Jonathan; US
WRIGHT, Jon E.; US
YONAN, Daniel E.; US
Priority Data:
62/676,59125.05.2018US
Title (EN) METHODS, ASSAYS, AND KITS FOR EVALUATING THE PERFORMANCE OF ENGINEERED LIVER TISSUE CONSTRUCTS
(FR) MÉTHODES, DOSAGES ET KITS D'ÉVALUATION DE LA PERFORMANCE DE CONSTRUCTIONS TISSULAIRES HÉPATIQUES MODIFIÉES
Abstract:
(EN) The disclosure provides methods, assays, and kits for evaluating performances of engineered liver tissue constructs, such as three-dimensional bioprinted liver tissue constructs, including in vitro, pre-implantation, and post-implantation performances. In some embodiments, the performances are evaluated using exosomal RNAs as biomarkers and in vitro sandwich culture assays.
(FR) L'invention concerne des méthodes, des dosages et des kits permettant d'évaluer des performances de constructions tissulaires hépatiques génétiquement modifiées, telles que des constructions tissulaires hépatiques biopsiques tridimensionnelles, comprenant des performances in vitro, de pré-implantation et de post-implantation. Dans certains modes de réalisation, les performances sont évaluées à l'aide d'ARN exosomaux en tant que biomarqueurs et dans des dosages de culture en sandwich in vitro.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)