WO2019220125 ANTIBACTERIAL COMPOUNDS

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Publication Number WO/2019/220125

Publication Date 21.11.2019

International Application No. PCT/GB2019/051349

International Filing Date 16.05.2019

IPC

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CPC

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Applicants

INFEX THERAPEUTICS LIMITED [GB]/[GB]

Inventors

WILKINSON, Andrew
COOPER, Ian
ORR, David
FINLAYSON, Jonathan
BUNT, Adam
APPELQVIST, Pia
WALLBERG, Hans
WÅNGSELL, Fredrik

Agents

HGF LIMITED

Priority Data

1807966.5		16.05.2018		GB
1905174.7		11.04.2019		GB

Publication Language English (en)

Filing Language English (EN)

Designated States

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Title

(EN) ANTIBACTERIAL COMPOUNDS

(FR) COMPOSÉS ANTIBACTÉRIENS

Abstract

(EN) This invention relates to compounds of formula (I) and methods of treatment using the compounds. The compounds of the invention can be used in combination with antibacterial agents to treat bacterial infections.More specifically, the compounds of formula (I) can be used in combination with a class of antibacterial agents known as carbapenems. The novel compounds of the present invention are enzyme inhibitors and more particularly are metallo-β-lactamase inhibitors.

(FR) La présente invention concerne des composés de formule (I) et des procédés de traitement utilisant ces composés. Les composés de l'invention peuvent être utilisés en combinaison avec des agents antibactériens pour traiter des infections bactériennes. Spécifiquement, les composés de formule (I) peuvent être utilisés en combinaison avec une classe d'agents antibactériens connus sous le nom de carbapénèmes. Les nouveaux composés de la présente invention sont des inhibiteurs enzymatiques et plus particulièrement des inhibiteurs de métallo-β-lactamase.

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
401	Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02	containing two hetero rings
04	directly linked by a ring-member-to-ring- member bond

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
207	Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
46	with hetero atoms directly attached to the ring nitrogen atom
48	Sulfur atoms

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
417	Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
02	containing two hetero rings
04	directly linked by a ring-member-to-ring- member bond

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
401	Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02	containing two hetero rings
08	linked by a carbon chain containing alicyclic rings

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
403	Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02	containing two hetero rings
04	directly linked by a ring-member-to-ring- member bond

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1. WO2019220125 - ANTIBACTERIAL COMPOUNDS

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
395	having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495	having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505	Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
506	not condensed and containing further heterocyclic rings

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31	Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04	Antibacterial agents

C	CHEMISTRY; METALLURGY
12	BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N	MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9	Enzymes; Proenzymes; Compositions thereof
14	Hydrolases (3)
78	acting on carbon to nitrogen bonds other than peptide bonds (3.5)
86	acting on amide bonds in cyclic amides, e.g. penicillinase ; (3.5.2)

Y	SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
02	TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
A	TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
50	in human health protection, e.g. against extreme weather
30	Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change