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1. WO2019217591 - ANTI-MSR1 ANTIBODIES AND METHODS OF USE THEREOF

Publication Number WO/2019/217591
Publication Date 14.11.2019
International Application No. PCT/US2019/031383
International Filing Date 08.05.2019
IPC
C07K 16/28 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
A61K 47/68 2017.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
68the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
CPC
A61K 2039/505
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
505comprising antibodies
A61K 31/165
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
16Amides, e.g. hydroxamic acids
165having aromatic rings, e.g. colchicine, atenolol, progabide
A61K 31/167
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
16Amides, e.g. hydroxamic acids
165having aromatic rings, e.g. colchicine, atenolol, progabide
167having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
A61K 31/417
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
41641,3-Diazoles
417Imidazole-alkylamines, e.g. histamine, phentolamine
A61K 31/4985
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two ; or more; nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines
4985Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
A61K 31/5383
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
535having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
53751,4-Oxazines, e.g. morpholine
5383ortho- or peri-condensed with heterocyclic ring systems
Applicants
  • REGENERON PHARMACEUTICALS, INC. [US]/[US]
Inventors
  • KYRATSOUS, Christos
  • NITTOLI, Thomas
  • ZUMSTEG, Anna
  • GROMADA, Jesper
  • GUSAROVA, Viktoria
  • HAN, Amy
  • HAXHINASTO, Sokol
  • MURPHY, Andrew J.
  • OLSON, William
  • SLEEMAN, Matthew
Agents
  • PATHAK, Rahul
  • SAHASRABUDHE, Kiran
  • KERRIGAN, Cameron
  • RICE, Janice
  • OSTOMEL, Todd
  • GUSLER, Gloria
  • REED, James
  • NOSON, Kevin
  • LIU, Qun
  • PAI, Raj
  • ANDERTON, Tom
Priority Data
62/669,27609.05.2018US
62/678,20030.05.2018US
62/769,94620.11.2018US
62/789,98708.01.2019US
62/821,36220.03.2019US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) ANTI-MSR1 ANTIBODIES AND METHODS OF USE THEREOF
(FR) ANTICORPS ANTI-MSR1 ET LEURS PROCÉDÉS D'UTILISATION
Abstract
(EN) Provided herein are antibodies and antigen-binding fragments that bind MSR1 and methods of use thereof. According to certain embodiments, the antibodies bind human MSR1 with high affinity. In certain embodiments, the antibodies bind MSR1 without blocking, or blocking less than 90%, of modified LDL binding to MSR1. In some embodiments, the antibodies bind cell surface expressed-MSR1 and are internalized. The antibodies of the invention may be fully human antibodies. The invention includes anti-MSR1 antibodies, or antigen-binding fragments thereof, conjugated to drugs or therapeutic compounds.
(FR) La présente invention concerne des anticorps et des fragments de liaison à l'antigène qui se lient à MSR1 ainsi que leurs procédés d'utilisation. Selon certains modes de réalisation de la présente invention, les anticorps se lient au MSR1 humain avec une forte affinité. Selon certains modes de réalisation de la présente invention, les anticorps se lient à MSR1 sans blocage, ou avec blocage d'au moins 90 % de LDL modifié se liant à MSR1. Selon certains modes de réalisation de la présente invention, les anticorps se lient à MSR1 exprimé à la surface cellulaire et sont internalisés. Les anticorps selon l'invention peuvent être des anticorps entièrement humains. L'invention concerne également des anticorps anti-MSR1, ou des fragments de liaison à l'antigène de ceux-ci, conjugués à des médicaments ou des composés thérapeutiques.
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