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1. WO2019215230 - DIGITAL QUALIMETRIC BIOMARKERS FOR DETERMINING INFORMATION PROCESSING SPEED

Publication Number WO/2019/215230
Publication Date 14.11.2019
International Application No. PCT/EP2019/061819
International Filing Date 08.05.2019
IPC
A61B 5/11 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes; Identification of persons
103Measuring devices for testing the shape, pattern, size or movement of the body or parts thereof, for diagnostic purposes
11Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
A61B 5/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes; Identification of persons
A61B 5/16 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes; Identification of persons
16Devices for psychotechnics; Testing reaction times
G16H 20/00 2018.1
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
20ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
G16H 50/20 2018.1
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
50ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
20for computer-aided diagnosis, e.g. based on medical expert systems
CPC
A61B 5/1124
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
103Detecting, measuring or recording devices for testing the shape, pattern, ; colour,; size or movement of the body or parts thereof, for diagnostic purposes
11Measuring movement of the entire body or parts thereof, e.g. head or hand tremor, mobility of a limb
1124Determining motor skills
A61B 5/162
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
16Devices for psychotechnics
162Testing reaction times
A61B 5/4082
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
40Detecting, measuring or recording for evaluating the nervous system
4076Diagnosing or monitoring particular conditions of the nervous system
4082Diagnosing or monitoring movement diseases, e.g. Parkinson, Huntington or Tourette
A61B 5/4088
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
40Detecting, measuring or recording for evaluating the nervous system
4076Diagnosing or monitoring particular conditions of the nervous system
4088Diagnosing of monitoring cognitive diseases, e.g. Alzheimer, prion diseases or dementia
A61B 5/7475
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
74Details of notification to user or communication with user or patient
7475User input or interface means, e.g. keyboard, pointing device, joystick
G16H 20/70
GPHYSICS
16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
20ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
70relating to mental therapies, e.g. psychological therapy or autogenous training
Applicants
  • F. HOFFMANN-LA ROCHE AG [CH]/[CH] (AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BE, BF, BG, BH, BJ, BN, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CL, CM, CN, CO, CR, CU, CY, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IR, IS, IT, JO, JP, KE, KG, KH, KM, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, ME, MG, MK, ML, MN, MR, MT, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SI, SK, SL, SM, SN, ST, SV, SY, SZ, TD, TG, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW)
  • HOFFMANN-LA ROCHE INC. [US]/[US] (US)
Inventors
  • BAKER, Mike
  • BELACHEW, Shibeshih Mitiku
  • GOSSENS, Christian
  • LINDEMANN, Michael
  • SPRENGEL, Jörg
Agents
  • ALTMANN STÖSSEL DICK PATENTANWÄLTE PARTG MBB
Priority Data
18171567.309.05.2018EP
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) DIGITAL QUALIMETRIC BIOMARKERS FOR DETERMINING INFORMATION PROCESSING SPEED
(FR) BIOMARQUEURS QUALIMÉTRIQUES NUMÉRIQUES POUR DÉTERMINER LA VITESSE DE TRAITEMENT D'INFORMATIONS
Abstract
(EN) The present invention relates to the field of neurological assessments and, in particular, to the assessment of Information Processing Speed in the context of drug research and development, diagnostics and patient and health care management. More specifically, it pertains to a computer-implemented method for automatically assessing information processing speed in a test subject comprising the steps of determining at least one first qualimetric activity parameter for sensorial transmission, cognition and motoric output activity and at least one second qualimetric activity parameter for sensorial transmission and motoric output activity in a preexisting dataset of cognitive oculomotor activity measurements obtained from said test subject, determining at least one third qualimetric activity parameter for cognition by comparing the said first and the said second qualimetric activity parameter to each other, and assessing the information processing speed in a subject based on the at least one first, second and third qualimetric activity parameter. The present invention further contemplates a method for determining cognitive impairment in a subject suspected to suffer therefrom comprising determining information processing speed, and determining the cognitive impairment based on the determined information processing speed. The invention also provides for a mobile device or system for carrying out the methods of the invention as well as the use of said mobile device or system for assessing information processing speed and/or cognitive impairment.
(FR) La présente invention concerne le domaine des évaluations neurologiques et, en particulier, l'évaluation de la vitesse de traitement d'informations dans le contexte de la recherche et de la mise au point de médicaments, du diagnostic et de la gestion du patient et des soins de santé. Plus particulièrement, l'invention concerne un procédé mis en œuvre par ordinateur pour évaluer automatiquement une vitesse de traitement d'informations chez un sujet de test, comprenant les étapes consistant à déterminer au moins un premier paramètre d'activité qualimétrique pour une transmission sensorielle, la cognition et l'activité de sortie motrice et au moins un deuxième paramètre d'activité qualimétrique pour une transmission sensorielle et une activité de sortie motrice dans un ensemble de données préexistantes de mesures d'activité oculomotrice cognitive obtenues à partir dudit sujet de test, à déterminer au moins un troisième paramètre d'activité qualimétrique pour la cognition par la comparaison dudit premier et dudit deuxième paramètre d'activité qualimétrique l'un à l'autre et à évaluer la vitesse de traitement d'informations chez un sujet sur la base dudit premier, deuxième et troisième paramètre d'activité qualimétrique. La présente invention concerne en outre un procédé pour déterminer une déficience cognitive chez un sujet suspecté de souffrir de celle-ci, comprenant la détermination de la vitesse de traitement d'informations et la détermination de la déficience cognitive sur la base de la vitesse de traitement d'informations déterminée. L'invention concerne également un dispositif ou un système mobile pour mettre en œuvre les procédés de l'invention ainsi que l'utilisation dudit dispositif ou système mobile pour évaluer la vitesse de traitement d'informations et/ou la déficience cognitive.
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