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1. WO2019213479 - POINT OF-CARE DIAGNOSTICS BASED ON A CHANGE IN PARTICLE MOTION BEHAVIOR

Publication Number WO/2019/213479
Publication Date 07.11.2019
International Application No. PCT/US2019/030540
International Filing Date 03.05.2019
IPC
A61K 41/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
41Medicinal preparations obtained by treating materials with wave energy or particle radiation
H02N 11/00 2006.1
HELECTRICITY
02GENERATION, CONVERSION, OR DISTRIBUTION OF ELECTRIC POWER
NELECTRIC MACHINES NOT OTHERWISE PROVIDED FOR
11Generators or motors not provided for elsewhere; Alleged perpetua mobilia obtained by electric or magnetic means
G01N 29/02 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
29Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
02Analysing fluids
G01N 29/22 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
29Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
22Details
CPC
B01D 61/00
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
61Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis, ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
B01L 2200/10
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
2200Solutions for specific problems relating to chemical or physical laboratory apparatus
10Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
B01L 2300/06
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
2300Additional constructional details
06Auxiliary integrated devices, integrated components
B01L 3/502715
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
3Containers or dishes for laboratory use, e.g. laboratory glassware
50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
502with fluid transport, e.g. in multi-compartment structures
5027by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
502715characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
C12Q 1/6816
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6813Hybridisation assays
6816characterised by the detection means
G01N 15/00
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
15Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
Applicants
  • THE BRIGHAM AND WOMEN'S HOSPITAL, INC. [US]/[US]
Inventors
  • SHAFIEE, Hadi
  • DRAZ, Mohamed Shehata
Agents
  • WESORICK, Richard S.
Priority Data
62/666,30903.05.2018US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) POINT OF-CARE DIAGNOSTICS BASED ON A CHANGE IN PARTICLE MOTION BEHAVIOR
(FR) DIAGNOSTICS DE POINT D'INTERVENTION BASÉS SUR UN CHANGEMENT DE COMPORTEMENT DE MOUVEMENT DE PARTICULES
Abstract
(EN) A system that monitors particle motion behavior for point-of-care diagnostics is described. The system can include a sample testing unit configured to house a sample. The sample testing unit can include a plurality of motor structures configured for self-propulsion based on a presence or an absence of a target analyte in the sample and a plurality of beads configured to experience a motion behavior based on the self-propulsion of the plurality of motor structures. Each of the plurality of motor structures can include a catalytic motor-like micro/nanoparticle; and an attached functional material specific for the target analyte attached to the catalytic motor-like particle. The optical recording unit can include an optical arrangement configured to detect the motion behavior of the beads in the sample testing unit. The motion behavior can be indicative of the presence or the absence of the target analyte.
(FR) Système qui surveille un comportement de mouvement de particules pour des diagnostics de point d'intervention. Le système peut comprendre une unité de test d'échantillon conçue pour loger un échantillon. L'unité de test d'échantillon peut comprendre une pluralité de structures de moteur conçues pour une auto-propulsion sur la base d'une présence ou d'une absence d'un analyte cible dans l'échantillon et une pluralité de billes conçues pour subir un comportement de mouvement sur la base de l'auto-propulsion de la pluralité de structures de moteur. Chaque structure de la pluralité de structures de moteur peut comprendre une micro/nanoparticule de type moteur catalytique ; et un matériau fonctionnel fixé spécifique pour l'analyte cible fixé à la particule de type moteur catalytique. L'unité d'enregistrement optique peut comprendre un agencement optique conçu pour détecter le comportement de mouvement des billes dans l'unité de test d'échantillon. Le comportement de mouvement peut indiquer la présence ou l'absence de l'analyte cible.
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