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1. WO2019209805 - METHOD OF MIXING A PHARMACEUTICAL SOLUTION AND MIXING SYSTEM

Publication Number WO/2019/209805
Publication Date 31.10.2019
International Application No. PCT/US2019/028686
International Filing Date 23.04.2019
IPC
B01F 1/00 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
FMIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
1Dissolving
B01F 3/08 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
FMIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
3Mixing, e.g. dispersing, emulsifying, according to the phases to be mixed
08liquids with liquids; Emulsifying
B01F 7/00 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
FMIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
7Mixers with rotary stirring devices in fixed receptacles; Kneaders
B01F 13/02 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
FMIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
13Other mixers; Mixing plant, including combinations of dissimilar mixers
02Mixers with gas agitation, e.g. with air supply tubes
B01F 15/00 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
FMIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
15Accessories for mixers
CPC
A61J 1/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
1Containers specially adapted for medical or pharmaceutical purposes
05for collecting, storing or administering blood, plasma or medical fluids
10Bag-type containers
A61J 1/2003
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
1Containers specially adapted for medical or pharmaceutical purposes
05for collecting, storing or administering blood, plasma or medical fluids
14Details ; , e.g. provisions for hanging or shape retaining means; Accessories therefor ; , e.g. inlet or outlet ports, filters or caps
20Arrangements for transferring ; or mixing; fluids, e.g. from vial to syringe
2003Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
A61J 1/2037
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
1Containers specially adapted for medical or pharmaceutical purposes
05for collecting, storing or administering blood, plasma or medical fluids
14Details ; , e.g. provisions for hanging or shape retaining means; Accessories therefor ; , e.g. inlet or outlet ports, filters or caps
20Arrangements for transferring ; or mixing; fluids, e.g. from vial to syringe
2003Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
202Separating means
2037having valve means
A61J 1/2082
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
1Containers specially adapted for medical or pharmaceutical purposes
05for collecting, storing or administering blood, plasma or medical fluids
14Details ; , e.g. provisions for hanging or shape retaining means; Accessories therefor ; , e.g. inlet or outlet ports, filters or caps
20Arrangements for transferring ; or mixing; fluids, e.g. from vial to syringe
2003Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
2079Filtering means
2082for gas filtration
B01F 1/0022
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
FMIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
1Dissolving
0022using flow mixing
B01F 1/0038
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
FMIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
1Dissolving
0038Dissolving systems, i.e. flow charts or diagrams; Arrangements, e.g. comprising controlling means
Applicants
  • BAXTER INTERNATIONAL INC. [US]/[US]
  • BAXTER HEALTHCARE SA [CH]/[CH]
Inventors
  • HURST, William, Spencer
  • WILLIAMS, Kent, Alan
  • SMITH, Donald, A.
  • WEHRLI, Michael, P.
  • CRIALES, Luis Ernesto, Escobar
  • TAM, Jessica
  • BIGALKE, Joseph, Edward
  • NAJDENI, Gert
  • ESSIEN, Michael, Imeobong
  • KERWELL, Karan
  • ZHOU, Lushan
Agents
  • MAHN, Giordana, H.
Priority Data
62/664,00527.04.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHOD OF MIXING A PHARMACEUTICAL SOLUTION AND MIXING SYSTEM
(FR) PROCÉDÉ DE MÉLANGE D'UNE SOLUTION PHARMACEUTIQUE ET SYSTÈME DE MÉLANGE
Abstract
(EN)
A method of mixing a pharmaceutical solution including adding a gas into an interior compartment of a mix bag to form a headspace. The interior compartment of the mix bag includes a top portion and a bottom portion. The headspace adjacent to the top portion contains gas. The method includes adding a solvent into the mix bag, and establishing a bubble column in the interior compartment by activating a recirculation assembly. The recirculation assembly includes a connecting pathway operably coupled to a recirculation pump. A first end of the connecting pathway is coupled to a top gas recirculation port and a second end is coupled to a bottom gas recirculation port of the mix bag such that the recirculation pump draws the gas from the headspace and delivers the gas to the interior compartment via the bottom gas recirculation port. The method includes adding a solute into the mix bag.
(FR)
L'invention concerne un procédé de mélange d'une solution pharmaceutique comprenant l'ajout d'un gaz dans un compartiment intérieur d'une poche de mélange pour former un espace libre. Le compartiment intérieur de la poche de mélange comprend une partie supérieure et une partie inférieure. L'espace libre adjacent à la partie supérieure contient du gaz. Le procédé consiste à ajouter un solvant dans la poche de mélange, et à mettre en place une colonne de bulles dans le compartiment intérieur par activation d'un ensemble de recirculation. L'ensemble de recirculation comprend un trajet de raccordement fonctionnellement lié à une pompe de recirculation. Une première extrémité du trajet de raccordement est reliée à un orifice de recirculation de gaz supérieur et une seconde extrémité est reliée à un orifice de recirculation de gaz inférieur de la poche de mélange de telle sorte que la pompe de recirculation aspire le gaz hors de l'espace libre et introduit le gaz dans le compartiment intérieur par l'intermédiaire de l'orifice de recirculation de gaz inférieur. Le procédé comprend l'ajout d'un soluté dans la poche de mélange.
Also published as
EP2019729874
Latest bibliographic data on file with the International Bureau