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1. WO2019209631 - CHIMERIC HLA ACCESSORY RECEPTOR

Publication Number WO/2019/209631
Publication Date 31.10.2019
International Application No. PCT/US2019/028201
International Filing Date 18.04.2019
IPC
C07K 14/74 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
74Major histocompatibility complex (MHC)
CPC
C07K 14/70539
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
70503Immunoglobulin superfamily
70539MHC-molecules, e.g. HLA-molecules
C07K 2319/03
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2319Fusion polypeptide
01containing a localisation/targetting motif
03containing a transmembrane segment
Applicants
  • BAYLOR COLLEGE OF MEDICINE [US]/[US]
Inventors
  • QUACH, David
  • ROONEY, Cliona, M.
Agents
  • SISTRUNK, Melissa, L.
Priority Data
62/661,33923.04.2018US
62/745,34113.10.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) CHIMERIC HLA ACCESSORY RECEPTOR
(FR) RÉCEPTEUR CHIMÈRE ACCESSOIRE D'HLA
Abstract
(EN)
Polypeptides comprising: (i) an MHC class I α polypeptide association domain, (ii) a transmembrane domain, and (iii) a signalling domain comprising an ITAM-containing sequence are disclosed. Also disclosed are nucleic acids and expression vectors encoding, compositions comprising, and methods using such polypeptides.
(FR)
L'invention concerne des polypeptides comprenant : (i) un domaine d'association polypeptidique de classe I de CMH, (ii) un domaine transmembranaire, et (iii) un domaine de signalisation comprenant une séquence contenant un ITAM. L'invention concerne également des acides nucléiques et des vecteurs d'expression codant, des compositions comprenant, et des procédés utilisant de tels polypeptides.
Also published as
EP2019725881
Latest bibliographic data on file with the International Bureau