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1. WO2019202599 - REAL-TIME MITOCHONDRIAL DIMENSION MEASUREMENTS

Publication Number WO/2019/202599
Publication Date 24.10.2019
International Application No. PCT/IL2019/050444
International Filing Date 17.04.2019
IPC
A61B 5/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes; Identification of persons
G01N 15/14 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
15Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
10Investigating individual particles
14Electro-optical investigation
CPC
G01N 15/1475
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
15Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
10Investigating individual particles
14Electro-optical investigation, e.g. flow cytometers
1468with spatial resolution of the texture or inner structure of the particle
1475using image analysis for extracting features of the particle
G01N 2015/1006
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
15Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
10Investigating individual particles
1006for cytology
G06K 9/0014
GPHYSICS
06COMPUTING; CALCULATING; COUNTING
KRECOGNITION OF DATA; PRESENTATION OF DATA; RECORD CARRIERS; HANDLING RECORD CARRIERS
9Methods or arrangements for reading or recognising printed or written characters or for recognising patterns, e.g. fingerprints
00127Acquiring and recognising microscopic objects, e.g. biological cells and cellular parts
0014Pre-processing, e.g. image segmentation
G06K 9/522
GPHYSICS
06COMPUTING; CALCULATING; COUNTING
KRECOGNITION OF DATA; PRESENTATION OF DATA; RECORD CARRIERS; HANDLING RECORD CARRIERS
9Methods or arrangements for reading or recognising printed or written characters or for recognising patterns, e.g. fingerprints
36Image preprocessing, i.e. processing the image information without deciding about the identity of the image
46Extraction of features or characteristics of the image
52by deriving mathematical or geometrical properties from the whole image
522Frequency domain transformation; Autocorrelation
Applicants
  • TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED [IL]/[IL]
Inventors
  • YANIV, Yael
  • LEICHNER, Joseph M.
  • KONYUKHOV, Evgene
Agents
  • GASSNER, Dvir
  • MINTOS, Moshe
  • GEYRA, Assaf
  • KESTEN, Dov
Priority Data
62/658,66217.04.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) REAL-TIME MITOCHONDRIAL DIMENSION MEASUREMENTS
(FR) MESURES DE DIMENSION MITOCHONDRIALE EN TEMPS RÉEL
Abstract
(EN)
A method comprising: receiving an image stream of a mammalian cardiac muscle cell; defining or having defined a region of interest (ROI) within said cell; calculating a fast Fourier transform (FFT) of said ROI; detecting peaks in said FFT; and determining at least one of sarcomere length, mitochondrial length, and mitochondrial width, based, at least in part, in said detected peaks
(FR)
L'invention concerne un procédé consistant à : recevoir un flux d'image d'une cellule de muscle cardiaque de mammifère; définir ou faire définir une région d'intérêt (ROI) à l'intérieur de ladite cellule; calculer une transformée de Fourier rapide (FFT) de ladite ROI; détecter des pics dans ladite FFT; et déterminer la longueur des sarcomères et/ou la longueur mitochondriale et/ou la largeur mitochondriale, sur la base, au moins en partie, desdits pics détectés.
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