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1. WO2019197642 - PERIODONTITIS DIAGNOSTIC METHODS, USES AND KITS

Publication Number WO/2019/197642
Publication Date 17.10.2019
International Application No. PCT/EP2019/059488
International Filing Date 12.04.2019
IPC
G01N 33/68 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
CPC
G01N 2333/4728
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2333Assays involving biological materials from specific organisms or of a specific nature
435from animals; from humans
46from vertebrates
47Assays involving proteins of known structure or function as defined in the subgroups
4701Details
4728alpha-Glycoproteins
G01N 2800/18
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2800Detection or diagnosis of diseases
18Dental and oral disorders
G01N 33/6893
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
6893related to diseases not provided for elsewhere
Applicants
  • KONINKLIJKE PHILIPS N.V. [NL]/[NL]
Inventors
  • KOOIJMAN, Gerben
  • RMAILE, Amir, Hussein
  • GLASSE, Carl
  • DE JAGER, Marinus, Karel, Johannes
  • CHAPPLE, Iain, Leslie, Campbell
  • GRANT, Melissa, Mackay
  • PRESHAW, Philip
  • TAYLOR, John, J
  • VAN HARTSKAMP, Michael, Alex
Agents
  • VAN OUDHEUSDEN-PERSET, Laure, E
  • DE HAAN, Poul, Erik
Priority Data
18166961.512.04.2018EP
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) PERIODONTITIS DIAGNOSTIC METHODS, USES AND KITS
(FR) MÉTHODES, UTILISATIONS ET KITS DE DIAGNOSTIC DE PARODONTITE
Abstract
(EN) Disclosed is an in vitro method for assessing whether a human patient has periodontitis. The method is based on the insight to determine biomarker proteins. Accordingly, in a sample of saliva a patient suffering from periodontitis, the concentrations are measured of the certain protein combinations. One such combination is Alpha-1-acid glycoprotein (A1AGP) and at least one of Profilin and S100 calcium-binding protein A9 (S100A9). Another combination is Pyruvate Kinase (PK) and S100 calcium-binding protein A8 (S100A8). Based on the concentrations as measured, a value is determined reflecting the joint concentrations for said proteins. This value is compared with a threshold value reflecting in the same manner the joint concentrations associated with periodontitis. The comparison allows assessing whether the testing value is indicative of the presence of periodontitis in said patient. Thereby, typically, a testing value reflecting a joint concentration below the joint concentration reflected by the threshold value is indicative for absence of periodontitis in said patient, and a testing value reflecting a joint concentration at or above the joint concentration reflected by the threshold value, is indicative for periodontitis in said patient.
(FR) L'invention concerne une méthode in vitro permettant d'évaluer si un patient humain est atteint d'une parodontite. La méthode est basée sur la connaissance pour déterminer des protéines de biomarqueurs. Par conséquent, dans un échantillon de salive d'un patient souffrant de parodontite, les concentrations de certaines combinaisons de protéines sont mesurées. Une telle combinaison est la glycoprotéine alpha-1-acide (A1AGP) et la profiline et/ou la protéine A9 se liant au calcium S100 (S100A9). Une autre combinaison est la pyruvate kinase (PK) et la protéine A8 se liant au calcium S100 (S100A8). Sur la base des concentrations mesurées, une valeur reflétant les concentrations communes desdites protéines est déterminée. Cette valeur est comparée à une valeur seuil reflétant de la même manière les concentrations communes associées à une parodontite. La comparaison permet d'évaluer si la valeur de test indique la présence d'une parodontite chez ledit patient. Ainsi, généralement, une valeur de test reflétant une concentration commune inférieure à la concentration commune reflétée par la valeur de seuil indique une absence de parodontite chez ledit patient, et une valeur de test reflétant une concentration commune égale ou supérieure à la concentration commune reflétée par la valeur de seuil, indique une parodontite chez ledit patient.
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