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1. WO2019197451 - GINGIVITIS DIAGNOSTIC METHODS, USES AND KITS

Publication Number WO/2019/197451
Publication Date 17.10.2019
International Application No. PCT/EP2019/059055
International Filing Date 10.04.2019
IPC
G01N 33/68 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
CPC
G01N 2800/18
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2800Detection or diagnosis of diseases
18Dental and oral disorders
G01N 33/6893
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
6893related to diseases not provided for elsewhere
Applicants
  • KONINKLIJKE PHILIPS N.V. [NL]/[NL]
Inventors
  • KOOIJMAN, Gerben
  • RMAILE, Amir, Hussein
  • GLASSE, Carl
  • DE JAGER, Marinus, Karel, Johannes
  • CHAPPLE, Iain, Leslie, Campbell
  • GRANT, Melissa, Mackay
  • PRESHAW, Philip
  • TAYLOR, John
  • VAN HARTSKAMP, Michael, Alex
Agents
  • MARSMAN, Albert, Willem
  • DE HAAN, Poul, Erik
Priority Data
18166949.012.04.2018EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) GINGIVITIS DIAGNOSTIC METHODS, USES AND KITS
(FR) MÉTHODES, UTILISATIONS ET KITS DE DIAGNOSTIC D'UNE GINGIVITE
Abstract
(EN)
Disclosed is an in vitro method for assessing whether a human patient has gingivitis. The method is based on the insight to determine biomarker proteins. Accordingly, in a sample of saliva a patient suffering from gingivitis, the concentrations are measured of the certain protein combinations. One such combination is Alpha-1-acid glycoprotein (A1AGP) and S100 calcium-binding protein A8 (S100A8), and at least one of Hemoglobin subunit beta (Hb-beta), Keratin 4 (K-4) and Pyruvate Kinase (PK). Another combination is Alpha-1-acid glycoprotein (A1AGP), Hemoglobin subunit beta (Hb-beta) and Keratin 4 (K-4). Based on the concentrations as measured, a value is determined reflecting the joint concentrations for said proteins. This value is compared with a threshold value reflecting in the same manner the joint concentrations associated with gingivitis. The comparison allows assessing whether the testing value is indicative of the presence of gingivitis in said patient. Thereby, typically, a testing value reflecting a joint concentration below the joint concentration reflected by the threshold value is indicative for absence of gingivitis in said patient, and a testing value reflecting a joint concentration at or above the joint concentration reflected by the threshold value, is indicative for gingivitis in said patient.
(FR)
L'invention concerne une méthode in vitro permettant d'évaluer si un patient humain présente une gingivite. La méthode est basée sur les connaissances permettant de déterminer des protéines de biomarqueurs. Par conséquent, dans un échantillon de salive d'un patient souffrant de gingivite, sont mesurées les concentrations de certaines associations de protéines. Une telle association consiste en l'alpha-1-glycoprotéine acide (A1AGP) et la protéine A8 S100 (S100A8) de liaison au calcium, et le sous-motif bêta de l'hémoglobine (Hb-beta), la kératine 4 (K4) et/ou la pyruvate kinase (PK). Une autre association consiste en l'alpha-1-glycoprotéine acide (A1AGP), le sous-motif bêta de l'hémoglobine (Hb-beta) et la kératine 4 (K4). Une valeur est déterminée sur la base des concentrations mesurées, celle-ci reflétant les concentrations jointes desdites protéines. Cette valeur est comparée à une valeur de seuil reflétant de la même manière les concentrations jointes associées à une gingivite. La comparaison permet d'évaluer si la valeur de test indique la présence d'une gingivite chez ledit patient. Ainsi, habituellement, une valeur de test reflétant une concentration jointe inférieure à la concentration jointe reflétée par la valeur de seuil indique l'absence d'une gingivite chez ledit patient, et une valeur de test reflétant une concentration jointe supérieure ou égale à la concentration jointe reflétée par la valeur de seuil indique une gingivite chez ledit patient.
Also published as
EP2019715510
RU2020136976
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