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1. WO2019197444 - GINGIVITIS DIAGNOSTIC METHODS, USES AND KITS

Publication Number WO/2019/197444
Publication Date 17.10.2019
International Application No. PCT/EP2019/059041
International Filing Date 10.04.2019
IPC
G01N 33/68 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
CPC
G01N 2333/47
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2333Assays involving biological materials from specific organisms or of a specific nature
435from animals; from humans
46from vertebrates
47Assays involving proteins of known structure or function as defined in the subgroups
G01N 2800/18
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2800Detection or diagnosis of diseases
18Dental and oral disorders
G01N 33/6803
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
6803General methods of protein analysis not limited to specific proteins or families of proteins
G01N 33/6893
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
6893related to diseases not provided for elsewhere
Applicants
  • KONINKLIJKE PHILIPS N.V. [NL]/[NL]
Inventors
  • KOOIJMAN, Gerben
  • RMAILE, Amir, Hussein
  • GLASSE, Carl
  • DE JAGER, Marinus, Karel, Johannes
  • CHAPPLE, Iain, Leslie, Campbell
  • GRANT, Melissa, Mackay
  • PRESHAW, Philip
  • TAYLOR, John
  • VAN HARTSKAMP, Michael, Alex
Agents
  • MARSMAN, Albert, Willem
  • DE HAAN, Poul, Erik
Priority Data
18166943.312.04.2018EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) GINGIVITIS DIAGNOSTIC METHODS, USES AND KITS
(FR) MÉTHODES, UTILISATIONS ET KITS DE DIAGNOSTIC DE GINGIVITE
Abstract
(EN)
Disclosed is an in vitro method for assessing whether a human patient has gingivitis. The method is based on the insight to determine biomarker proteins. Accordingly, in a sample of saliva a patient suffering from gingivitis, the concentrations are measured of the certain protein combinations. One such combination is Alpha-1-acid glycoprotein (A1AGP) and at least one of Matrix metalloproteinase-8 (MMP8), Matrix metalloproteinase-9 (MMP9), Hepatocyte growth factor (HGF), Hemoglobin subunit beta (Hb-beta), and S100 calcium-binding protein A8 (S100A8). Based on the concentrations as measured, a value is determined reflecting the joint concentrations for said proteins. This value is compared with a threshold value reflecting in the same manner the joint concentrations associated with gingivitis. The comparison allows assessing whether the testing value is indicative of the presence of gingivitis in said patient. Thereby, typically, a testing value reflecting a joint concentration below the joint concentration reflected by the threshold value is indicative for absence of gingivitis in said patient, and a testing value reflecting a joint concentration at or above the joint concentration reflected by the threshold value, is indicative for gingivitis in said patient.
(FR)
L'invention concerne une méthode in vitro permettant d'évaluer si un patient humain est atteint d'une gingivite. La méthode est basée sur la connaissance pour déterminer des protéines de biomarqueurs. Par conséquent, dans un échantillon de salive d'un patient souffrant de gingivite, les concentrations des certaines combinaisons de protéines sont mesurées. Une telle combinaison est la glycoprotéine alpha-1-acide (A1AGP) et au moins l'un de la métalloprotéase matricielle-8 (MMP8), de la métalloprotéase matricielle-9 (MMP9), du facteur de croissance des hépatocytes (HGF), de la sous-unité bêta de l'hémoglobine (Hb-bêta) et de la protéine A8 de liaison au calcium S100 (S100A8). Sur la base des concentrations mesurées, une valeur reflétant les concentrations communes desdites protéines est déterminée. Cette valeur est comparée à une valeur seuil reflétant de la même manière les concentrations communes associées à une gingivite. La comparaison permet d'évaluer si la valeur de test indique la présence d'une gingivite chez ledit patient. Ainsi, généralement, une valeur de test reflétant une concentration commune inférieure à la concentration commune reflétée par la valeur seuil indique une absence de gingivite chez ledit patient, et une valeur de test reflétant une concentration commune égale ou supérieure à la concentration commune reflétée par la valeur seuil indique une gingivite chez ledit patient.
Also published as
EP2019715503
RU2020136741
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