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1. WO2019197327 - METHOD FOR INCREASING THE YIELD OF OXIDOSQUALENE, TRITERPENES AND/OR TRITERPENOIDS AND HOST CELL THEREFORE

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Publication Number WO/2019/197327
Publication Date 17.10.2019
International Application No. PCT/EP2019/058789
International Filing Date 08.04.2019
IPC
C12N 9/04 2006.1
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12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
02Oxidoreductases (1.), e.g. luciferase
04acting on CHOH groups as donors, e.g. glucose oxidase, lactate dehydrogenase (1.1)
C12N 9/88 2006.1
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12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
88Lyases (4.)
C12N 9/90 2006.1
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9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
90Isomerases (5.)
C12N 15/09 2006.1
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NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
C12N 15/63 2006.1
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15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
C12P 5/00 2006.1
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PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
5Preparation of hydrocarbons
CPC
C12N 1/16
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1Microorganisms, e.g. protozoa; Compositions thereof
14Fungi
16Yeasts; Culture media therefor
C12N 1/18
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1Microorganisms, e.g. protozoa; Compositions thereof
14Fungi
16Yeasts; Culture media therefor
18Baker's yeast; Brewer's yeast
C12N 15/52
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15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
52Genes encoding for enzymes or proenzymes
C12N 15/81
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15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
80for fungi
81for yeasts
C12N 2500/20
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2500Specific components of cell culture medium
05Inorganic components
10Metals; Metal chelators
20Transition metals
C12N 9/0006
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NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes; Proenzymes; Compositions thereof
0004Oxidoreductases (1.)
0006acting on CH-OH groups as donors (1.1)
Applicants
  • FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. [DE]/[DE]
  • WESTFÄLISCHE WILHELMS-UNIVERSITÄT MÜNSTER [DE]/[DE]
Inventors
  • SCHULZE GRONOVER, Christian
  • BOJE MÜLLER, Lowis Gerrit
  • VAN DEENEN, Nicole
  • BROEKER, Jan Niklas
Agents
  • WEINZIERL, Gerhard
  • KOCH, Andreas Dr.
  • SCHIWECK, Wolfram Dr.
Priority Data
18166374.109.04.2018EP
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) METHOD FOR INCREASING THE YIELD OF OXIDOSQUALENE, TRITERPENES AND/OR TRITERPENOIDS AND HOST CELL THEREFORE
(FR) PROCÉDÉ POUR AUGMENTER LE RENDEMENT D'OXYDOSQUALÈNE, DE TRITERPÈNES ET/OU DE TRITERPÉNOÏDES ET CELLULE HÔTE ASSOCIÉE
Abstract
(EN) The present invention relates to a method of increasing the yield of at least one of oxidosqualene, triterpenes and/or triterpenoids in a specifically engineered host cell and a respective host cell as well as to the use of said host cell for manufacturing the at least one of oxidosqualene, triterpenes and/or triterpenoids.
(FR) La présente invention concerne un procédé d'augmentation du rendement d'au moins un élément parmi de l'oxydosqualène, des triterpènes et/ou des triterpénoïdes dans une cellule hôte génétiquement modifiée et une cellule hôte respective, ainsi que l'utilisation de ladite cellule hôte pour la fabrication dudit au moins un élément parmi les oxydosqualènes, les triterpènes et/ou les triterpénoïdes.
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