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1. WO2019197200 - METHODS, USES AND KITS FOR MONITORING OR PREDICTING RESPONSE TO PERIODONTAL DISEASE TREATMENT

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Publication Number WO/2019/197200
Publication Date 17.10.2019
International Application No. PCT/EP2019/058213
International Filing Date 02.04.2019
IPC
G01N 33/68 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
CPC
G01N 2333/4727
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2333Assays involving biological materials from specific organisms or of a specific nature
435from animals; from humans
46from vertebrates
47Assays involving proteins of known structure or function as defined in the subgroups
4701Details
4727Calcium binding proteins, e.g. calmodulin
G01N 2333/4728
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2333Assays involving biological materials from specific organisms or of a specific nature
435from animals; from humans
46from vertebrates
47Assays involving proteins of known structure or function as defined in the subgroups
4701Details
4728alpha-Glycoproteins
G01N 2333/4742
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2333Assays involving biological materials from specific organisms or of a specific nature
435from animals; from humans
46from vertebrates
47Assays involving proteins of known structure or function as defined in the subgroups
4701Details
4742Keratin; Cytokeratin
G01N 2333/545
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2333Assays involving biological materials from specific organisms or of a specific nature
435from animals; from humans
52Assays involving cytokines
54Interleukins [IL]
545IL-1
G01N 2333/96494
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2333Assays involving biological materials from specific organisms or of a specific nature
90Enzymes; Proenzymes
914Hydrolases (3)
948acting on peptide bonds (3.4)
95Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
964derived from animal tissue
96425from mammals
96427in general
9643with EC number
96486Metalloendopeptidases (3.4.24)
96491with definite EC number
96494Matrix metalloproteases, e. g. 3.4.24.7
G01N 2800/18
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2800Detection or diagnosis of diseases
18Dental and oral disorders
Applicants
  • KONINKLIJKE PHILIPS N.V. [NL]/[NL]
Inventors
  • KOOIJMAN, Gerben
  • VAN HARTSKAMP, Michael Alex
  • RMAILE, Amir Hussein
  • GLASSE, Carl
  • PRESHAW, Philip
  • TAYLOR, John
  • CHAPPLE, Iain Leslie Campbell
  • GRANT, Melissa Mackay
  • DE JAGER, Marinus Karel Johannes
Agents
  • MARSMAN, Albert Willem
  • DE HAAN, Poul, Erik
Priority Data
18166935.912.04.2018EP
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) METHODS, USES AND KITS FOR MONITORING OR PREDICTING RESPONSE TO PERIODONTAL DISEASE TREATMENT
(FR) MÉTHODES, UTILISATIONS ET KITS DE SURVEILLANCE OU DE PRÉDICTION D'UNE RÉACTION À UN TRAITEMENT DE MALADIE PARODONTALE
front page image
Abstract
(EN) Disclosed is an in vitro method for assessing or predicting the response of a human patient to treatment of periodontal disease. The method is based on the insight to determine biomarker proteins. Accordingly, in a sample of saliva of a patient, the concentrations are measured of certain protein combinations. One such combination is Alpha-1-acid glycoprotein (A1AGP) and at least one of Interleukin-1-beta (IL-1β) and 5 Matrix metalloproteinase-8 (MMP-8). Based on the concentrations as measured, at least one value is determined reflecting the joint concentrations for said proteins. This at least one value may indicate the probability that human patient has been or will be successfully treated for the periodontitis. The at least one value can be compared with at least one threshold value reflecting in the same manner the joint concentrations associated with successful treatment of 10 periodontitis. The comparison allows assessing whether the testing value is indicative of the periodontal treatment status in said patient.
(FR) L'invention concerne une méthode in vitro d'évaluation ou de prédiction de la réaction d'un patient humain au traitement d'une maladie parodontale. La méthode est basée sur la connaissance pour déterminer des protéines de biomarqueurs. Par conséquent, les concentrations de certaines combinaisons de protéines sont mesurées dans un échantillon de salive d'un patient. Une telle combinaison est la glycoprotéine alpha-1-acide (A1AGP) et l'interleukine-1-bêta (IL-1β) et/ou la métalloprotéase matricielle-8 (MMP-8). Sur la base des concentrations mesurées, au moins une valeur reflétant les concentrations communes desdites protéines est déterminée. Ladite valeur peut indiquer la probabilité de traitement avec succès passé ou futur de la parodontite chez le patient humain. Ladite valeur peut être comparée à au moins une valeur seuil reflétant de la même manière les concentrations communes associées à un traitement réussi de la parodontite. La comparaison permet d'évaluer si la valeur de test indique l’état de traitement parodontal chez ledit patient.
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