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1. WO2019178129 - SUBSTITUTED IMIDAZOPYRIDINES AS INHIBITORS OF PLASMA KALLIKREIN AND USES THEREOF

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Publication Number WO/2019/178129
Publication Date 19.09.2019
International Application No. PCT/US2019/021897
International Filing Date 12.03.2019
IPC
C07D 471/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
A61K 31/437 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
4353ortho- or peri-condensed with heterocyclic ring systems
437the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
A61P 29/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
C07D 519/00 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
519Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/ or C07D455/257
A61P 9/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
CPC
A61K 31/437
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
4353ortho- or peri-condensed with heterocyclic ring systems
437the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
A61P 27/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
27Drugs for disorders of the senses
02Ophthalmic agents
A61P 29/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
A61P 7/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
7Drugs for disorders of the blood or the extracellular fluid
10Antioedematous agents; Diuretics
A61P 9/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
C07D 471/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
Applicants
  • SHIRE HUMAN GENETIC THERAPIES, INC. [US]/[US]
Inventors
  • PAPAIOANNOU, Nikolaos
  • FINK, Sarah Jocelyn
  • MILLER, Thomas Allen
  • SHIPPS, Gerald Wayne, Jr.
  • TRAVINS, Jeremy Mark
  • EHMANN, David Edward
  • RAE, Alastair
  • ELLARD, John Mark
Agents
  • MONG, Surin K.
  • ADATO, Ronen
  • AUGST, Alexander
  • BUTEAU, Kristen C.
  • BYCHOWSKI, Meaghan E.
  • D'AMATO, Erica M.
  • FORCIER, John V.
  • HALEY, Christopher K.
  • HAULBROOK, William R.
  • HAWVER, Lisa A.
  • JARRELL, Brenda Herschbach
  • KLEIN, Daniel A.
  • LI, Bin
  • LI, Xiaodong
  • LYON, Charles E.
  • MEDINA, Rolando
  • MONROE, Margo R.
  • PACE, Nicholas J.
  • PYSHER, Paul A.
  • REARICK, John P.
  • REESE, Brian E.
  • SAHR, Robert N.
  • SCHMITT, Michael
  • SCHONEWALD, Stephanie L.
  • SHINALL, Michael A.
  • SHORE, David E.
  • SMITH, Maria C.
  • SUH, Su Kyung
  • TSE, Janet M.
  • VETTER, Michael L.
  • VRABLIK, Tracy L.
Priority Data
62/642,37613.03.2018US
62/757,72808.11.2018US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) SUBSTITUTED IMIDAZOPYRIDINES AS INHIBITORS OF PLASMA KALLIKREIN AND USES THEREOF
(FR) IMIDAZOPYRIDINES SUBSTITUÉES EN TANT QU'INHIBITEURS DE LA KALLICRÉINE PLASMATIQUE ET LEURS UTILISATIONS
front page image
Abstract
(EN) The present invention provides compounds and compositions thereof which are useful as inhibitors of plasma kallikrein and which exhibit desirable characteristics for the same.
(FR) La présente invention concerne des composés et des compositions de ceux-ci qui sont utiles en tant qu'inhibiteurs de la kallicréine plasmatique et qui présentent des caractéristiques souhaitables à cet effet.
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