Processing

Please wait...

Settings

Settings

Goto Application

1. WO2019175773 - COMPOSITIONS FOR USE IN THE TREATMENT OF MUSCULOSKELETAL CONDITIONS AND METHODS FOR PRODUCING THE SAME LEVERAGING THE SYNERGISTIC ACTIVITY OF TWO DIFFERENT TYPES OF MESENCHYMAL STROMAL/STEM CELLS

Publication Number WO/2019/175773
Publication Date 19.09.2019
International Application No. PCT/IB2019/052006
International Filing Date 12.03.2019
IPC
C12N 5/0775 2010.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
071Vertebrate cells or tissues, e.g. human cells or tissues
077Mesenchymal cells, e.g. bone cells, cartilage cells, marrow stromal cells, fat cells or muscle cells
0775Mesenchymal stem cells; Adipose-tissue derived stem cells
A61K 35/28 2015.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
28Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
CPC
A61K 35/28
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
28Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
A61K 35/32
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
32Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
A61K 35/51
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
48Reproductive organs
51Umbilical cord; Umbilical cord blood; Umbilical stem cells
A61K 38/18
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
18Growth factors; Growth regulators
A61K 38/19
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
19Cytokines; Lymphokines; Interferons
A61P 19/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
02for joint disorders, e.g. arthritis, arthrosis
Applicants
  • UNIVERSIDADE DO PORTO [PT]/[PT]
Inventors
  • SANTOS, Ana
  • PEDROSA, Sílvia
  • BRANQUINHO, Mariana
  • ALVITES, Rui
  • MAURICIO, Ana
  • CAMÕES, Sérgio
  • RODRIGUES, Joana
  • MIRANDA, Joana
  • SANTOS, Jorge
  • REIS, Inês
Agents
  • GATA, Lígia
Priority Data
11061712.03.2018PT
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) COMPOSITIONS FOR USE IN THE TREATMENT OF MUSCULOSKELETAL CONDITIONS AND METHODS FOR PRODUCING THE SAME LEVERAGING THE SYNERGISTIC ACTIVITY OF TWO DIFFERENT TYPES OF MESENCHYMAL STROMAL/STEM CELLS
(FR) COMPOSITIONS DESTINÉES À ÊTRE UTILISÉES DANS LE TRAITEMENT D'AFFECTIONS MUSCULO-SQUELETTIQUES ET MÉTHODES DE PRODUCTION DE CELLES-CI TIRANT PROFIT DE L'ACTIVITÉ SYNERGIQUE DE DEUX TYPES DIFFÉRENTS DE CELLULES SOUCHES/STROMALES MÉSENCHYMATEUSES
Abstract
(EN) The present invention relates to compositions comprising mesenchymal stem cells (MSC) useful for producing pharmaceutical formulation to treat musculoskeletal conditions, including joint degeneration, tendon and ligament laxity or rupture, and muscle conditions. The present invention relates to the field of regenerative medicine, namely formulating improved compositions for the treatment of musculoskeletal conditions, including joint degeneration, tendon and ligament laxity or rupture, and muscle conditions, having a positive impact on pharmaceutical formulations containing mesenchymal stem cells (MSCs), providing the enhancement of MSCs viability upon cryopreservation, MSCs stability during transportation and manipulation, and MSCs therapeutic efficacy of the final formulations.
(FR) La présente invention concerne des compositions comprenant des cellules souches mésenchymateuses (MSC) utiles pour produire une formulation pharmaceutique pour traiter des affections musculo-squelettiques, comprenant une dégénérescence articulaire, une laxité ou une rupture de tendon et de ligament, et des affections musculaires. La présente invention concerne le domaine de la médecine régénérative, à savoir la formulation de compositions améliorées pour le traitement d'affections musculo-squelettiques, comprenant une dégénérescence articulaire, une laxité ou une rupture de tendon et de ligament, et des affections musculaires, ayant un impact positif sur des formulations pharmaceutiques contenant des cellules souches mésenchymateuses (MSC), fournissant l'amélioration de la viabilité des MSC lors de la cryoconservation, la stabilité des MSC pendant le transport et la manipulation, et l'efficacité thérapeutique des MSC des formulations finales.
Related patent documents
Latest bibliographic data on file with the International Bureau