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1. WO2019164997 - 2,2,2-TRIFLUOROACETIC ACID 1-(2,4-DIMETHYLPHENYL)-2-[(3-METHOXYPHENYL) METHYLENE] HYDRAZIDE POLYMORPHS AND METHOD OF MAKING THE SAME

Publication Number WO/2019/164997
Publication Date 29.08.2019
International Application No. PCT/US2019/018835
International Filing Date 20.02.2019
IPC
A61K 31/31 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
28Compounds containing heavy metals
305Mercury compounds
31containing nitrogen
A61K 31/175 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
16Amides, e.g. hydroxamic acids
17having the group N-C(O)-N or N-C(S)-N, e.g. urea, thiourea, carmustine
175having the group , N-C(O)-N=N- or , e.g. carbonohydrazides, carbazones, semicarbazides, semicarbazones; Thioanalogues thereof
A61P 25/28 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
28for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
CPC
A61K 31/175
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
16Amides, e.g. hydroxamic acids
17having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
175having the group , >N—C(O)—N=N— or , e.g. carbonohydrazides, carbazones, semicarbazides, semicarbazones; Thioanalogues thereof
A61K 31/31
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
28Compounds containing heavy metals
305Mercury compounds
31containing nitrogen
A61P 25/28
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
28for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
C07B 2200/13
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
2200Indexing scheme relating to specific properties of organic compounds
13Crystalline forms, e.g. polymorphs
C07C 249/16
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
249Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
16of hydrazones
C07C 251/86
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
251Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
72Hydrazones
86having doubly-bound carbon atoms of hydrazone groups bound to carbon atoms of six-membered aromatic rings
Applicants
  • O'NEIL, Michael [US]/[US]
  • KIDON, Barbara [US]/[US]
  • JANZ, Bill [US]/[US]
  • WU, Hongqiao [US]/[US]
Inventors
  • KIDON, Barbara
  • JANZ, Bill
  • WU, Hongqiao
Agents
  • PILLSBURY WINTHROP SHAW PITTMAN LLP
Priority Data
62/633,44121.02.2018US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) 2,2,2-TRIFLUOROACETIC ACID 1-(2,4-DIMETHYLPHENYL)-2-[(3-METHOXYPHENYL) METHYLENE] HYDRAZIDE POLYMORPHS AND METHOD OF MAKING THE SAME
(FR) POLYMORPHES DU 1-(2,4-DIMÉTHYLPHÉNYL)-2-[(3-MÉTHOXYPHÉNYL)MÉTHYLÈNE]HYDRAZIDE DE L'ACIDE 2,2,2-TRIFLUOROACÉTIQUE ET LEUR PROCÉDÉ DE PRÉPARATION
Abstract
(EN) Crystalline polymorph forms of neurotrophic agent 2,2,2-trifluoroacetic acid 1-(2,4- Dimethylphenyl)-2-[(3-methoxyphenyl)methylene]hydrazide (J147), and process for producing the crystalline polymorphic form are provided.
(FR) L'invention concerne des formes polymorphes cristallines d'un agent neurotrophique du 1-(2,4-diméthylphényl)-2-[(3-méthoxyphényl)méthylène]hydrazide de l'acide 2,2,2-trifluoroacétique (J147), et un processus de production de la forme polymorphe cristalline.
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