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1. WO2019143824 - SOLID FORMS OF FASORACETAM

Publication Number WO/2019/143824
Publication Date 25.07.2019
International Application No. PCT/US2019/014022
International Filing Date 17.01.2019
IPC
A61K 31/19 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19Carboxylic acids, e.g. valproic acid
CPC
A61K 31/454
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non condensed pyridines; Hydrogenated derivatives thereof
445Non condensed piperidines, e.g. piperocaine
4523containing further heterocyclic ring systems
454containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
C07B 2200/13
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
2200Indexing scheme relating to specific properties of organic compounds
13Crystalline forms, e.g. polymorphs
C07C 205/57
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
205Compounds containing nitro groups bound to a carbon skeleton
49the carbon skeleton being further substituted by carboxyl groups
57having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
C07C 229/60
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
229Compounds containing amino and carboxyl groups bound to the same carbon skeleton
52having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
54with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
60with amino and carboxyl groups bound in meta- or para- positions
C07C 275/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
275Derivatives of urea, i.e. compounds containing any of the groups , the nitrogen atoms not being part of nitro or nitroso groups
02Salts; Complexes; Addition compounds
Applicants
  • THE CHILDREN'S HOSPITAL OF PHILADELPHIA [US]/[US]
Inventors
  • LEYSSENS, Tom
  • COUCH, Richard Alan
  • GUILLOT, Michael Paul René
  • HARMSEN, Bram
  • BAILEY, Thomas R.
  • APPELMANS, Martin
Agents
  • RIGAUT, Kathleen, D.
Priority Data
62/619,06218.01.2018US
62/668,09207.05.2018US
62/683,32511.06.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) SOLID FORMS OF FASORACETAM
(FR) FORMES À L'ÉTAT SOLIDE DE FASORACÉTAM
Abstract
(EN)
The disclosure is directed to cocrystals of fasoracetam, including R-fasoracetam, and various coformers. Crystalline materials comprising fasoracetam, including R-fasoracetam, are also provided. The disclosure further includes pharmaceutical compositions and methods of treatment of the cocrystals and crystalline materials of the disclosure.
(FR)
L'invention concerne des co-cristaux de fasoracétam, notamment du R-fasoracétam, et divers co-formeurs. L'invention concerne également des matières cristallines comprenant du fasoracétam, y compris du R-fasoracétam. L'invention concerne en outre des compositions pharmaceutiques et des procédés de traitement des cocristaux et des matières cristallines de l'invention.
Also published as
EP2019741128
Latest bibliographic data on file with the International Bureau