WO2019142126 SUBSTITUTED ALKYNYLENE COMPOUNDS AS ANTICANCER AGENTS

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Publication Number WO/2019/142126

Publication Date 25.07.2019

International Application No. PCT/IB2019/050387

International Filing Date 17.01.2019

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Applicants

AURIGENE DISCOVERY TECHNOLOGIES LIMITED [IN]/[IN]

Inventors

CHIKKANNA, Dinesh
KHAIRNAR, Vinayak V.
RAMACHANDRA, Muralidhara
SATYAM, Leena Khare

Priority Data

201841001978

17.01.2018

Publication Language English (en)

Filing Language English (EN)

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Title

(EN) SUBSTITUTED ALKYNYLENE COMPOUNDS AS ANTICANCER AGENTS

(FR) COMPOSÉS ALCYNYLÈNE SUBSTITUÉS EN TANT QU'AGENTS ANTICANCÉREUX

Abstract

(EN) The present invention relates to substituted alkynylene compounds represented by compound of formula (I) pharmaceutically acceptable salts and stereoisomers thereof. The present invention further provides the methods of preparation of compound of formula (I) and therapeutic uses thereof as anti-cancer agents.

(FR) La présente invention concerne des composés alcynylène substitués représentés par le composé de formule (I), des sels pharmaceutiquement acceptables et des stéréo-isomères de ceux-ci. La présente invention concerne en outre les procédés de préparation du composé de formule (I) et leurs utilisations thérapeutiques en tant qu'agents anticancéreux.

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
401	Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
401	Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
16	Amides, e.g. hydroxamic acids
17	having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
395	having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435	having six-membered rings with one nitrogen as the only ring hetero atom
439	the ring forming part of a bridged ring system, e.g. quinuclidine

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
395	having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435	having six-membered rings with one nitrogen as the only ring hetero atom
44	Non condensed pyridines; Hydrogenated derivatives thereof
445	Non condensed piperidines, e.g. piperocaine
4468	having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl

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1. WO2019142126 - SUBSTITUTED ALKYNYLENE COMPOUNDS AS ANTICANCER AGENTS

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35	Antineoplastic agents

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
C	ACYCLIC OR CARBOCYCLIC COMPOUNDS
237	Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
24	having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton