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1. WO2019133969 - ENHANCED CHIMERIC ANTIGEN RECEPTORS AND USES THEREOF

Publication Number WO/2019/133969
Publication Date 04.07.2019
International Application No. PCT/US2018/068134
International Filing Date 31.12.2018
IPC
C07K 14/705 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
C07K 14/725 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
725T-cell receptors
C12N 15/09 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
CPC
A61K 2039/5156
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
51comprising whole cells, viruses or DNA/RNA
515Animal cells
5156expressing foreign proteins
A61K 2039/5158
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
51comprising whole cells, viruses or DNA/RNA
515Animal cells
5158Antigen-pulsed cells, e.g. T-cells
A61K 39/001112
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
0005Vertebrate antigens
0011Cancer antigens
001102Receptors, cell surface antigens or cell surface determinants
001111Immunoglobulin superfamily
001112CD19, B4
A61K 48/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
C07K 16/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
C07K 2317/622
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
60characterized by non-natural combinations of immunoglobulin fragments
62comprising only variable region components
622Single chain antibody (scFv)
Applicants
  • MEMORIAL SLOAN-KETTERING CANCER CENTER [US]/[US]
Inventors
  • SADELAIN, Michel
  • FEUCHT, Judith
  • HAMIEH, Mohamad
  • SUN, Jie
  • MANSILLA-SOTO, Jorge A.
Agents
  • LENDARIS, Steven P.
  • LENDARIS, Steven, P.
Priority Data
62/612,03129.12.2017US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ENHANCED CHIMERIC ANTIGEN RECEPTORS AND USES THEREOF
(FR) RÉCEPTEURS ANTIGÉNIQUES CHIMÉRIQUES AMÉLIORÉS ET LEURS UTILISATIONS
Abstract
(EN)
The presently disclosed subject matter provides methods and compositions for enhancing the immune response toward cancers and pathogens. It relates to novel designs of chimeric antigen receptors (CARs) and engineered immunoresponsive cells comprising the same. The engineered immunoresponsive cells comprising the novel CARs are antigen-directed and have extended persistence without compromising function.
(FR)
La présente invention concerne des procédés et des compositions pour améliorer la réponse immunitaire vis-à-vis des cancers et des agents pathogènes. L'invention concerne de nouvelles conceptions de récepteurs antigéniques chimériques (CAR) et des cellules immunoréactives génétiquement modifiées les comprenant. Les cellules immunoréactives génétiquement modifiées comprenant les nouveaux CAR sont dirigées contre l'antigène et présentent une persistance étendue sans compromettre la fonction.
Also published as
IL275619
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