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1. (WO2019123011) TRIAZOLOQUINAZOLINONE SYNTHESIS
Latest bibliographic data on file with the International BureauSubmit observation

Pub. No.: WO/2019/123011 International Application No.: PCT/IB2018/001573
Publication Date: 27.06.2019 International Filing Date: 19.12.2018
IPC:
C07D 487/04 (2006.01) ,A61P 25/20 (2006.01) ,A61P 25/22 (2006.01) ,A61K 31/519 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
20
Hypnotics; Sedatives
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
22
Anxiolytics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519
ortho- or peri-condensed with heterocyclic rings
Applicants:
GABATHER AB [SE/SE]; Bygg 215 N Forskargatan 20 J 15136 Södertälje, SE
Inventors:
JAGUSCH, Thomas; DE
ZENHORST, Peter Adrianus, Hubertus; NL
VAN DER AA, Paula Anna, Adriana; NL
VERSPUI, Govert, Arie; NL
KAS, Martin; CZ
SCIGELOVA, Martina; CZ
Agent:
RAPHAEL, Aaron, M.; US
Priority Data:
62/607,35319.12.2017US
Title (EN) TRIAZOLOQUINAZOLINONE SYNTHESIS
(FR) SYNTHÈSE DE TRIAZOLOQUINAZOLINONE
Abstract:
(EN) The invention relates to an improved process for preparing triazoloquinazolinones of Formula (I), including 9-benzyl-2-(4-methylphenyl)-2,6-dihydro[l,2,4]triazolo[4,3-c]quinazoline-3,5-dione, pharmaceutical compositions comprising the compounds of Formula (I), including 9-benzyl-2-(4- methylphenyl)-2,6-dihydro[l,2,4]triazolo[4,3-c]quinazoline-3,5-dione, prepared by the improved process, and methods of treatment using the compounds of Formula (I), including 9-benzyl-2-(4- methylphenyl)-2,6-dihydro[l,2,4]triazolo[4,3-c]quinazoline-3,5-dione, prepared by the improved process.
(FR) L'invention concerne un procédé amélioré de préparation de triazoloquinazolinones de formule (I), comprenant du 9-benzyl-2-(4-méthylphényle)-2,6-dihydro[l,2,4]triazolo[4,3-c]quinazoline-3,5-dione, des compositions pharmaceutiques comprenant les composés de formule (I), comprenant du 9-benzyl-2-(4-méthylphényl))-2,6-dihydro[l, 2,4]triazolo[4,3-c]quinazoline-3,5-dione, préparé par le procédé amélioré, et des méthodes de traitement à l'aide des composés de formule (I), comprenant du 9-benzyl-2-(4-méthylphényl)-2,6-dihydro[l, 2,4]triazolo[4,3-c]quinazoline-3,5-dione, préparée par le procédé amélioré.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)