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1. WO2019104086 - POLYMORPHS AND SOLID FORMS OF A PYRIMIDINYLAMINO-PYRAZOLE COMPOUND, AND METHODS OF PRODUCTION

Publication Number WO/2019/104086
Publication Date 31.05.2019
International Application No. PCT/US2018/062102
International Filing Date 20.11.2018
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
405
Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
413
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
14
containing three or more hetero rings
C07D 403/12 (2006.01)
C07D 403/14 (2006.01)
C07D 405/14 (2006.01)
C07D 413/14 (2006.01)
CPC
A61K 9/20
A61P 25/28
C07B 2200/13
C07D 403/12
Applicants
  • DENALI THERAPEUTICS INC. [US/US]; 151 Oyster Point Blvd South San Francisco, California 94080, US
Inventors
  • REMARCHUK, Travis; US
  • SUDHAKAR, Anantha; US
Agents
  • ANDRUS, Alex; US
  • HARRIS, Robert J.; US
  • VIKSNINS, Ann S.; US
  • MALEN, Peter L.; US
  • KRUEGER, Katherine A.D.; US
  • MICKELSON, John W.; US
  • PADYS, Dan J.; US
Priority Data
62/589,27621.11.2017US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) POLYMORPHS AND SOLID FORMS OF A PYRIMIDINYLAMINO-PYRAZOLE COMPOUND, AND METHODS OF PRODUCTION
(FR) POLYMORPHES ET FORMES SOLIDES D'UN COMPOSÉ DE PYRIMIDINYLAMINO-PYRAZOLE, ET PROCÉDÉS DE PRODUCTION
Abstract
(EN)
The present disclosure relates to crystalline polymorph and amorphous forms 2-methyl-2-(3-methyl-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-1H-pyrazol-1-yl)propanenitrile or solvates, tautomers, and pharmaceutically acceptable salts or cocrystals thereof, and processes for their preparation.
(FR)
La présente invention concerne un polymorphe cristallin et des formes amorphes de 2-méthyl-2-(3-méthyl-4-(4-(méthylamino)-5-(trifluorométhyl)pyrimidin-2-ylamino)-1H-pyrazol-1-yl) propanenitrile ou des solvates, des tautomères, et des sels ou co-cristaux pharmaceutiquement acceptables de ceux-ci, et des procédés pour leur préparation.
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